胶体银有用也可能有害

我对胶体银不是很熟悉，不怀疑有很多用处。已有很多文献记叙了胶体银的用途和危害。这里，我只是猜测如果把胶体银喝下去，一种可能的危害。体内的蛋白和其他分子可牢固地吸附在胶体银表面，蛋白构形会因吸附而有所改变。表面吸附了蛋白的纳米级胶体银，可以进入血液，进入各组织后很难排出。由于胶体银是免疫佐剂（增强抗原的免疫反应），有可能使吸附了构形改变的自身蛋白的胶体银，成为自身抗原，时间久了，可能会导致自身免疫疾病。长期沉积在体内，难以排除引发自身免疫病的可能性。下面的文献1，综述胶体银的用途并提到胶体银可用作动物实验疫苗佐剂。文献2 是一个内服胶体银致病的案例报告。    

我的看法纯属猜测。我对制备纳米胶体金及其应用有过长期的经验。

参看：

1. The Impact of Engineered Silver Nanomaterials on the Immune System，https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712063/
2. Colloidal Silver Ingestion Associated with Leukocytoclastic Vasculitis in an Adolescent Female, Published online 2019 May 23. doi: 10.12659/AJCR.915499

文献2 节录和机器翻译：

患者：女性，19 岁

最终诊断：白细胞破碎性血管炎

症状：疲劳 • 关节 • 疼痛 • 肌肉 • 疼痛 • 瘙痒 • 皮疹

背景：

白细胞破碎性血管炎是一种小血管疾病，在儿童中并不常见。在本病例报告中，我们介绍了一个与摄入胶体银（一种自然疗法药物）相关的白细胞破碎性血管炎的青少年病例。该报告强调了患者的表现和诱导剂的罕见性。

案例报告：

一名 19 岁女性因面部和颈部出现严重皮疹而在急诊科就诊，随后在就诊当天继续以颅尾方式扩散，累及躯干、背部、上肢和下肢。最近没有旅行，没有宠物，也没有风湿病或自身免疫性疾病的阴性家族史。在急诊科就诊前，她的家庭药物包括用于“内部清洁”的胶体银 4 周。一旦临床医生意识到胶体银的持续摄入，建议患者停药。患者开始使用甲基强的松龙，初步诊断为血管炎，同时使用秋水仙碱治疗。注意到皮疹在 24 小时内从面部消退。在 5 天的住院期间，患者的皮疹和瘙痒继续缓慢改善。

结论：

摄入一种自然疗法药物胶体银导致我们的患者出现大量白细胞破碎性血管炎，由于疾病的严重程度需要住院治疗。停止摄入胶体银后症状消失。由于未知的安全摄入浓度和潜在的副作用，应不鼓励使用胶体银。

Patient: Female, 19

Final Diagnosis: Leukocytoclastic vasculitis

Symptoms: Fatigue • joint • pain • muscle • pain • pruritis • rash

Background:

Leukocytoclastic vasculitis is a disease of the small vessels and is uncommon in children. In this case report, we present an adolescent case of leukocytoclastic vasculitis associated with the ingestion of colloidal silver, a naturopathic drug. This report highlights the rarity of the patient’s presentation and inducing agent.

Case report:

A 19-year-old female presented in the Emergency Department with severe rash on the face, and neck, and then continued to spread in a craniocaudal fashion during the day of presentation to involve trunk, back, upper and lower extremities. There was no recent travel, no pets and a negative family history for rheumatologic or autoimmune diseases. Her home medications included colloidal silver for “internal cleansing” for 4 weeks prior to Emergency Department presentation. Once the clinicians were aware of the continued ingestion of colloidal silver, the patient was advised to discontinue the drug. The patient was started on methylprednisolone with preliminary diagnosis of vasculitis, as well as concurrent therapy with colchicine. The rash was noted to be receding from the face within 24 hours. Over a hospital course of 5 days, the patient’s rash and pruritus continued to slowly improve.

Conclusions:

The ingestion of a naturopathic drug, colloidal silver, caused vast leukocytoclastic vasculitis in our patient warranting hospitalization due to the extent of the disease. The symptoms resolved after discontinuation of colloidal silver ingestion. Due to unknown safe ingestion concentrations and potential side effects, use of colloidal silver should be discouraged.