此反应最早由WilliamJohnson在1961年发现。他原本尝试用9-二甲锍基芴与苯甲醛进行类似Wittig反应合成烯烃，结果两者反应得到了环氧亚苄基芴，偶然发现了此反应。1962年，E.J.Corey和M.Chaykovsky发现利用钠氢对三甲基卤化锍（trimethylsulfoxoniumhalides）脱质子可以得到一种活性化合物，二甲基亚砜亚甲基叶立德【dimethylsulfoxoniummethylide(I)，Corey叶立德】。简单的醛酮与其反应可以得到环氧[阅读全文]
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(2023-03-04 16:57:06)
此反应最早由WilliamJohnson在1961年发现。他原本尝试用9-二甲锍基芴与苯甲醛进行类似Wittig反应合成烯烃，结果两者反应得到了环氧亚苄基芴，偶然发现了此反应。1962年，E.J.Corey和M.Chaykovsky发现利用钠氢对三甲基卤化锍（trimethylsulfoxoniumhalides）脱质子可以得到一种活性化合物，二甲基亚砜亚甲基叶立德【dimethylsulfoxoniummethylide(I)，Corey叶立德】。简单的醛酮与其反应可以得到环氧[阅读全文]
(2023-03-01 20:07:41)
TheSeyferth–Gilberthomologationisachemicalreactionofanarylketone1(oraldehyde)withdimethyl(diazomethyl)phosphonate2andpotassiumtert-butoxidetogivesubstitutedalkynes3.Dimethyl(diazomethyl)phosphonate2isoftencalledtheSeyferth–Gilbertreagent.Thisreactioniscalledahomologationbecausetheproducthasexactlyoneadditionalcarbonmorethanthestartingmaterial.DeprotonationoftheSeyferth–Gilbertrea...[阅读全文]
(2023-03-01 16:24:58)
Ingeneral,DIwaterisexpectedtocontainmoreimpuritiesthanHPLCwater,whichusuallyhasbeenthroughextrastepstoremovethelastresiduesofionicimpurities,aswellasmanyorganicspeciesusingcarbonandUVstages.SomedetectorsmaynotlikeDIwater.
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(2023-02-28 17:42:36)
近日，随着各大跨国药企2022年财报的陆续发布，全球畅销药TOP10名单也随之出炉。排在前三位的分别是辉瑞/BioNtech的Comirnaty、艾伯维/卫材的Humira以及默沙东的Keytruda，销售额分别为378.1亿美元、212.4亿美元、209.4亿美元。新冠相关产品仍是“摇钱树”新冠疫苗和新冠口服药在前5名畅销药中占据了3个名额，分别是辉瑞的新冠疫苗Comirnaty和新冠口服药Paxlovid，以及Moderna的新冠[阅读全文]
(2023-02-26 11:35:26)
Asidefromyourcar’sfuel,therightsizeofthewheelsalsoplaysakeyroleinkeepingyourvehicleintip-topshape.Ifyouhavenoticed,asidefromthebrandofyourtiresthereareothermarkingsonit,particularlylettersandnumbers.Whatdotiresizenumbersmean?Andwhatdotheselettersonmytiresmean? Thesenumbersandletterstellalotofinformationaboutthetires’purpose,itsdimensions,theloadcapacityitcouldhold,anditsdurabili...[阅读全文]
(2023-02-22 16:45:21)
格氏试剂与氧气的反应一般分为如下2个步骤： 格氏试剂与O2反应先形成过氧化物。 过氧化物与另一分子格氏试剂反应形成ROMgX。ROMgX在被水淬灭后，则生成ROH，即醇或酚。 一般而言，芳基格氏试剂比烷基格氏试剂对氧气更稳定一些。 更直观的机理如下所示： 如果有其他合适的金属离子存在下，也会发生格氏试剂的自偶联反应： 具体案例： 来自网络 参考文[阅读全文]
(2023-02-22 16:39:54)
TheBarton–McCombiedeoxygenationisanorganicreactioninwhichahydroxyfunctionalgroupinanorganiccompoundisreplacedbyahydrogentogiveanalkylgroup.ItisnamedafterBritishchemistsSirDerekHaroldRichardBartonandStuartW.McCombie.Thereactionmechanismconsistsofacatalyticradicalinitiationstepandapropagationstep.Thealcohol(1)isfirstconvertedintoareactivecarbonothioylintermediatesuchasathionoesterorxanthate2.H...[阅读全文]
(2023-02-21 19:36:12)
Stryker'sreagent([(PPh3)CuH]6),alsoknownastheOsborncomplex,isahexamericcopperhydrideligatedwithtriphenylphosphine.Itisabrickred,air-sensitivesolid.Stryker'sreagentisamildlyhydridicreagent,usedinhomogeneouscatalysisofconjugatereductionreactionsofenones,enoates,andrelatedsubstrates. Thecompoundcaneffectregioselectiveconjugatereductionsofvariouscarbonylderivativesincludingunsaturatedal...[阅读全文]
(2023-02-20 19:28:26)
Diethylaluminumcyanide("Nagata'sreagent")istheorganoaluminumcompoundwithformula((C2H5)2AlCN)n.Thiscolorlesscompoundisusuallyhandledasasolutionintoluene.Itisareagentforthehydrocyanationofα,β-unsaturatedketones. Synthesis Diethylaluminumcyanidewasoriginallygeneratedbytreatmentoftriethylaluminumwithaslightexcessofhydrogencyanide.Theproductistypicallystoredinampoulesbeca...[阅读全文]
(2023-02-20 19:20:12)
TheNicholasreactionisanorganicreactionwhereadicobaltoctacarbonyl-stabilizedpropargyliccationisreactedwithanucleophile.Oxidativedemetallationgivesthedesiredalkylatedalkyne.ItisnamedafterKennethM.Nicholas.ThePauson–Khandreaction(orPKRorPK-typereaction)isachemicalreactiondescribedasa[2+2+1]cycloadditionbetweenanalkyne,analkeneandcarbonmonoxidetoformaα,β-cyclopentenone.IhsanUllahKhand...[阅读全文]
