hedonic eating dopaminergic brain circuit 享乐性进食

“享乐性进食（Hedonic eating）被定义为出于食物的可口性而非生理需求的摄食行为。然而，对可口食物摄入的神经调控机制仍知之甚少。我们发现，享乐性进食受一条来自peri–...的神经通路控制。”

 the Chinese translation of 超越享乐性进食

一种多巴胺能脑回路驱动小鼠的食物摄取
Dana M. Small 著
发表于《科学》（Science）
2025年3月27日
第387卷，第6741期，第1353-1354页
DOI: 10.1126/science.adw3646

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摘要
将能量以脂肪形式储存的能力，使动物能够为未来确保能量储备。在这种背景下，超越饱腹感的进食是一种有益的、适应性的行为。然而，在许多人类群体中，这种适应性行为因高能量密度食物的轻易获取而变得不再适应，导致肥胖率居高不下。其中一种行为，称为“激活行为”（invigoration），会导致对可口食物的摄入速度、持续时间及摄入量的增加。然而，这种行为背后的神经机制尚不清楚。

在本期第1376页，Zhu等人报道了一个驱动小鼠“进食激活”行为的脑回路。该回路起始于蓝斑周围区域（periLC）的神经元，并导致伏隔核中的多巴胺释放。该发现揭示了一个神经靶点，未来通过对其进行治疗性调控，可能有望通过阻止激活行为来改变食物摄入。 "Beyond hedonic eating A dopaminergic brain circuit drives food consumption in mice Dana M. Small Authors Info & Affiliations Science 27 Mar 2025 Vol 387, Issue 6741 pp. 1353-1354 DOI: 10.1126/science.adw3646 1,063 Metrics Total Downloads 1,063 Last 6 Months 1,063 Last 12 Months 1,063 Abstract References and Notes eLetters (0) Information & Authors Metrics & Citations Check Access References Share Abstract The capacity to store energy as fat enables animals to ensure energy reserves for the future. In this context, eating beyond satiety (fullness) is a beneficial, adaptive behavior. However, in many human populations, this adaptive behavior is made maladaptive by readily available, energy-dense sources of food, resulting in high rates of obesity. One such behavior, called invigoration, causes an increase in speed, duration, and intake of a palatable food (1). The neural mechanisms underlying this behavior are not yet clear. On page 1376 of this issue, Zhu et al. (2) report a brain circuit that drives feeding invigoration in mice. This circuit begins with neurons in the area around the locus coeruleus (periLC) and results in dopamine release in the nucleus accumbens. The finding provides a neural target, the therapeutic modulation of which might enable changes to food intake by preventing invigoration."