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Caveolin 1 From Wikipedia, the free encyclopedia Jump to navigat

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Caveolin 1

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CAV1
 
Identifiers
Aliases CAV1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, Caveolin 1
External IDs OMIM: 601047 MGI: 102709 HomoloGene: 1330 GeneCards: CAV1
hideGene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CAV1
Genomic location for CAV1
Band 7q31.2 Start 116,525,001 bp[1]
End 116,561,184 bp[1]
hideRNA expression pattern
PBB GE CAV1 203065 s at fs.png

PBB GE CAV1 212097 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
 
 
Ensembl
 
 
UniProt
 
 
RefSeq (mRNA)
 

NM_001753
NM_001172895
NM_001172896
NM_001172897

 

NM_001243064
NM_007616

RefSeq (protein)
 

NP_001166366
NP_001166367
NP_001166368
NP_001744

 

NP_001229993
NP_031642

Location (UCSC) Chr 7: 116.53 – 116.56 Mb Chr 6: 17.31 – 17.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.[5]

Function[edit]

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.[6]

Interactions[edit]

Caveolin 1 has been shown to interact with heterotrimeric G proteins,[7] Src tyrosine kinases (SrcLyn) and H-Ras,[8] cholesterol,[9] TGF beta receptor 1,[10] endothelial NOS,[11] androgen receptor,[12] amyloid precursor protein,[13] gap junction protein, alpha 1,[14] nitric oxide synthase 2A,[15] epidermal growth factor receptor,[16] endothelin receptor type B,[17] PDGFRB,[18] PDGFRA,[18] PTGS2,[19] TRAF2,[20][21] estrogen receptor alpha,[22] caveolin 2,[23][24] PLD2,[25][26] Bruton's tyrosine kinase[27] and SCP2.[28] All these interactions are through a caveolin-scaffolding domain (CSD) within caveolin-1 molecule.[8] Molecules that interact with caveolin-1 contain caveolin-binding motifs (CBM).[29]

See also[edit]

References[edit]

  1. Jump up to:a b c GRCh38: Ensembl release 89: ENSG00000105974 - Ensembl, May 2017
  2. Jump up to:a b c GRCm38: Ensembl release 89: ENSMUSG00000007655 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:"National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:"National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (March 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics56 (3): 355–6. doi:10.1006/geno.1998.5723PMID 10087206.
  6. ^ "Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa".
  7. ^ Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I, Lisanti MP (June 1995). "Evidence for a regulated interaction between heterotrimeric G proteins and caveolin"The Journal of Biological Chemistry270 (26): 15693–701. doi:10.1074/jbc.270.26.15693PMID 7797570.
  8. Jump up to:a b Li S, Couet J, Lisanti MP (November 1996). "Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases"The Journal of Biological Chemistry271 (46): 29182–90. doi:10.1074/jbc.271.46.29182PMC 6687395PMID 8910575.
  9. ^ Li S, Song KS, Lisanti MP (January 1996). "Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes"The Journal of Biological Chemistry271 (1): 568–73. doi:10.1074/jbc.271.1.568PMID 8550621.
  10. ^ Razani B, Zhang XL, Bitzer M, von Gersdorff G, Böttinger EP, Lisanti MP (March 2001). "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor"The Journal of Biological Chemistry276 (9): 6727–38. doi:10.1074/jbc.M008340200PMID 11102446.
  11. ^ García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC (November 1996). "Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1"The Journal of Biological Chemistry271 (44): 27237–40. doi:10.1074/jbc.271.44.27237PMID 8910295.
  12. ^ Lu ML, Schneider MC, Zheng Y, Zhang X, Richie JP (April 2001). "Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation"The Journal of Biological Chemistry276 (16): 13442–51. doi:10.1074/jbc.M006598200PMID 11278309.
  13. ^ Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T (April 1998). "Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein"The Journal of Biological Chemistry273 (17): 10485–95. doi:10.1074/jbc.273.17.10485PMID 9553108.
  14. ^ Schubert AL, Schubert W, Spray DC, Lisanti MP (May 2002). "Connexin family members target to lipid raft domains and interact with caveolin-1". Biochemistry41 (18): 5754–64. doi:10.1021/bi0121656PMID 11980479.
  15. ^ Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells"Proceedings of the National Academy of Sciences of the United States of America97 (26): 14334–9. Bibcode:2000PNAS...9714334Fdoi:10.1073/pnas.250406797PMC 18919PMID 11114180.
  16. ^ Couet J, Sargiacomo M, Lisanti MP (November 1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities"The Journal of Biological Chemistry272 (48): 30429–38. doi:10.1074/jbc.272.48.30429PMID 9374534.
  17. ^ Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T (April 2003). "Regulated interaction of endothelin B receptor with caveolin-1". European Journal of Biochemistry270 (8): 1816–27. doi:10.1046/j.1432-1033.2003.03544.xPMID 12694195.
  18. Jump up to:a b Yamamoto M, Toya Y, Jensen RA, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Experimental Cell Research247 (2): 380–8. doi:10.1006/excr.1998.4379PMID 10066366.
  19. ^ Liou JY, Deng WG, Gilroy DW, Shyue SK, Wu KK (September 2001). "Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts"The Journal of Biological Chemistry276 (37): 34975–82. doi:10.1074/jbc.M105946200PMID 11432874.
  20. ^ Feng X, Gaeta ML, Madge LA, Yang JH, Bradley JR, Pober JS (March 2001). "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors"The Journal of Biological Chemistry276 (11): 8341–9. doi:10.1074/jbc.M007116200PMID 11112773.
  21. ^ Cao H, Courchesne WE, Mastick CC (March 2002). "A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase"The Journal of Biological Chemistry277 (11): 8771–4. doi:10.1074/jbc.C100661200PMID 11805080.
  22. ^ Schlegel A, Wang C, Pestell RG, Lisanti MP (October 2001). "Ligand-independent activation of oestrogen receptor alpha by caveolin-1"The Biochemical Journal359 (Pt 1): 203–10. doi:10.1042/0264-6021:3590203PMC 1222136PMID 11563984.
  23. ^ Breuza L, Corby S, Arsanto JP, Delgrossi MH, Scheiffele P, Le Bivic A (December 2002). "The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells"Journal of Cell Science115 (Pt 23): 4457–67. doi:10.1242/jcs.00130PMID 12414992.
  24. ^ Scherer PE, Lewis RY, Volonte D, Engelman JA, Galbiati F, Couet J, Kohtz DS, van Donselaar E, Peters P, Lisanti MP (November 1997). "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo"The Journal of Biological Chemistry272 (46): 29337–46. doi:10.1074/jbc.272.46.29337PMID 9361015.
  25. ^ Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation"The Journal of Investigative Dermatology121 (6): 1487–95. doi:10.1111/j.1523-1747.2003.12614.xPMID 14675200.
  26. ^ Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, Liscovitch M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Letters467(2–3): 326–32. doi:10.1016/S0014-5793(00)01174-1PMID 10675563S2CID 21891748.
  27. ^ Vargas L, Nore BF, Berglof A, Heinonen JE, Mattsson PT, Smith CI, Mohamed AJ (March 2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx"The Journal of Biological Chemistry277 (11): 9351–7. doi:10.1074/jbc.M108537200PMID 11751885.
  28. ^ Zhou M, Parr RD, Petrescu AD, Payne HR, Atshaves BP, Kier AB, Ball JM, Schroeder F (June 2004). "Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo"Biochemistry43 (23): 7288–306. doi:10.1021/bi035914nPMID 15182174.
  29. ^ Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP (March 1997). "Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins"The Journal of Biological Chemistry272 (10): 6525–33. doi:10.1074/jbc.272.10.6525PMID 9045678.

Further reading

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