The Twitter back and forth between the two, who once dated back in 2010 and have been on good terms since, began on Monday after 50 Cent shared a screenshot of a Fox News report on Joe Biden's proposed tax plan.
According to reports, taxpayers in New York City, New Jersey and California who earn more than $400,000 could see their combined state and local rates rise above 60%. While 50 didn't get into any of that context in his tweet, he made it clear he'd be putting his money first when it came to the election.
"WHAT THE F--K! (VOTE ForTRUMP) IM OUT, F--K NEW YORK The KNICKS never win anyway," he tweeted. "I don't care Trump doesn't like black people 62% are you out of ya f--king mind."
The rapper quickly started trending over his support and it wasn't long until Handler jumped into his replies -- tweeting, "You used to be my favorite ex-boyfriend."
50 didn't love that, joking that the election was "effecting [sic] my love life now." He added, "@chelseahandler I love ya Gator, don't let Trump and Joe Biden come between us girl."