就地给创伤患者静脉输液会增加死亡的危险

The longstanding practice of first giving severely wounded trauma patients intravenous (IV) fluids before bringing them to a trauma center may actually raise their risk of death, a new study suggests.

The finding flies in the face of common medical wisdom and mandated protocols in some states that require that IV fluids be given to trauma patients immediately if their blood pressure drops precipitously.

But a fresh analysis of data on nearly 777,000 trauma patients revealed that, overall, those who are given pre-hospital IV fluids are actually 11 percent more likely to die than those who aren't, not only because of transport delays but also in part because of the increased risk for bleeding that can accompany a fluid-induced increase in blood pressure.

"IV fluid administration to trauma patients pre-hospital is like one of those things that's been thought of as mainstay, and that got implemented before there was science that showed it was actually the best thing to do," said study author Dr. Elliott R. Haut, an associate professor in both the department of surgery and the department of anesthesiology & critical care at the Johns Hopkins University School of Medicine in Baltimore. "And now of course it's a standard of care. And it's very hard to buck the trend with respect to something that's been done for 25 years."

But, he added, "the general idea here is that although obviously everybody has the best of intentions it might be that not all of the procedures we do for injured people are beneficial."

Haut, who is also the director of the Trauma/Acute Care Surgery Fellowship at the Johns Hopkins Hospital, and his colleagues report the findings in the February issue of the Annals of Surgery.

Most of the patients in the analysis were male, white and under 40, the research team noted, and about half were administered IV fluids before transportation to a trauma center.

Haut and his associates found that on top of the 11 percent overall higher risk of death among such patients, some types of trauma patients faced an even worse prognosis when given a pre-hospital IV.

For example, patients whose injuries were due to a stabbing or shooting were found to face a 25 percent elevated risk of death if they were given a pre-hospital IV, relative to those who weren't. And those with severe head injuries and/or those who ultimately underwent emergency surgery in the hospital appeared to face a 35 percent greater risk of death if administered a pre-transport IV.

"I certainly don't think that this study is the final answer to the question about pre-hospital fluids," acknowledged Haut. "But I do think that we can see here that it's not always beneficial, and may actually be harmful."

Wally Ghurabi, emergency department director at the Santa Monica-UCLA Medical Center in Santa Monica, Calif., described the finding as "fascinating."

"On the one hand, this is really a question of plumbing, because you want to try and keep the patient's condition status quo until you get him in to the hospital. But if the patient has lost a liter of blood and you immediately water it down with an IV then you raise the patient's blood pressure, and that can change the patient's condition before you get him in," Ghurabi explained.

"So, then it all depends on the pre-hospital timing situation. Are you next door to a hospital or three hours away? Are you in New York City, one block away from NYU? That's one thing. But if you're in a rural area very far away, that's another. So there's potential here for some common sense to factor into the decision-making process," he added.

"And this study opens the door for us to talk about these issues," Ghurabi continued. "Right now, we have very specific pre-hospital criteria that we currently teach paramedics. And what we teach is to do the IV before taking the trauma patient in. But this study should get us to talk about that approach. And I think it should be open for discussion."

-By Alan Mozes（HealthDay）