MeSO2ClTheformationofmesylateswithmethanesulfonylchloride(MeSO2Cl)isusuallyaccomplishedwithabase(ex.TEAorpyridine),inasolventsuchasDCM,withcoolingoratRT.Apossibleside-pdtisthecorrespondingalkylchloride(seeAlcoholtoChloride-SulfonylChlorides).Example1ToasolutionoftheSM(300mg,2.30mmol)inDCM(6mL)at0CwasaddedTEA(0.64mL,4.6mmol)followedbyMeSO2Cl(0.21mL,2.76mmol).Thereactionmixturewasstirredat0Cfor30min...[
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化学酷2023-08-1500:01[
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Thiscolorlessoilyliquidhasabitteralmondodorathigherconcentration.
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DAST(DiethylaminosulfurTrifluoride)OtherNames:N,N-Diethylaminosulfurtrifluoride(Diethylamino)sulfurtrifluorideDiethyl(trifluorosulfido)amineStructure:CASNumber:38078-09-0MolecularWeight:161.19g/molAppearance:ColorlessoilBoilingPoint:30-32Cat3mmHgDensity:1.22g/mLDiethylaminosulfurtrifluoride(DAST)isanucleophilicfluorinatingagentwithwideuseinorganicchemistry.Deoxo-Fluorismorethermallystablealternati...[
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TransesterificationistheprocessofexchangingtheorganicfunctionalgroupR″ofanesterwiththeorganicgroupR'ofanalcohol.Thesereactionsareoftencatalyzedbytheadditionofanacidorbasecatalyst.Thereactioncanalsobeaccomplishedwiththehelpofotherenzymes,particularlylipases(oneexampleisthelipaseE.C.3.1.1.3).
Strongacidscatalysethereactionbydonatingaprotontothecarbonylgroup,thusmakingitamorepotentel...[
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Theweigelaflorida'RedPrince'genuswasnamedinhonoroftheGermanscientist,ChristianWeigel.AnancientspeciesfromAsia,fossilevidencesuggeststheseplantshavebeenpresentformillionsofyears,althoughtheydidnotreachEuropeuntilthe19thcentury.Thishardyplantperformsbestwheninfullsun.Thetube-shapedflowersaretheperfectfitforhummingbirdsandthesweetnectarattractsahostofotherpollinators.
Theweigelaflorida'...[
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Peegeehydrangea(Hydrangeapaniculata'Grandiflora'),oftenwrittenaspeegee,isaparticularlycold-hardyhydrangeavariety.Thisshrub'sbloomsformlargecone-shapedclusters(panicles)ofwhiteflowersthatdevelopapinkorpurpletintovertime.PeegeehydrangeaishardyinUSDAZones3through8,makingitagreatshrubselectionforlandscapesincoldclimateswhereothertypesofhydrangeaswon'tgrowsuccessfully.Peegeehydrangeasar...[
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PatDussault,UniversityofNebraska-Lincolnpdussault1@unl.eduAugust1,201IntroductionandleadingreferencesThefollowingprovidesabriefintroductiontotheapplicationofozonolysiswithinacademiclabs.Ozonolysisremainsamongthemostfrequentlyusedofmethodsforoxidativecleavageofalkenes.Whilebestknownasameansbywhichtointroducealdehydesandketones,ozonolysiscanalsobeusedtogenerateotherfunctionalgroups.Anoverviewofsomeo...[
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OrganicRoute有机合成路线2023-07-2409:45甲基以及烷基（杂）芳香类化合物苄位上溴反应可以说是有机合成化学中最常见的反应类型之一了，反应属于自由基类型，反应生成的苄溴类合成砌块，在医药研发中应用非常广泛，可以与各种亲核试剂反应，像叠氮化钠，胺类，苯酚类，硫醇类等等。这类反应通常使用卤代溶剂，用的最多的是四氯化碳和二氯甲烷，引发剂一般使用BPO(Benzoylper[
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OrganicRoute有机合成路线2023-07-2522:05羧酸还原为醇是有机合成中最常见的转化反应之一，可以通过硼烷，四氢铝锂等强还原剂直接实现。除此之外，也可以通过活化羧酸的方式，从而在硼氢化钠的参与下实现羧酸还原为伯醇。在研发类公司，最常见的方法是混酐方法，羧酸预先与氯甲酸酯（常用氯甲酸异丁酯）生成混酐，硼氢化钠还原高产率得到产物。1995年，RajivSharma等人报道[
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