H2O2/DMSO体系水解腈制备酰胺

1989年，Alan R. Katritzky就报道了一种H2O2-K2CO3-DMSO体系水解腈为伯酰胺的方法【Synthesis 1989, 949】，室温下，5-30分钟就能完成反应，是一种非常实用的水解腈制备酰胺的方法。

此反应的机理研究报道于【Bulletin of the Chemical Society of Japan, 1981, 54, 793-799】

反应操作

 

To a stirred solution of 4-chlorobenzonitrile (1.37 g, 0.01 mol) in DMSO (3 ml), cooled in a ice bath, was added 30% H2O2 (1.2 ml) and K2CO3, the reaction was allowed to warm up to r.t. (strong exothermic effect was observed). After 5 min., distilled water (50 ml) was added, cooling applied, and the product was collected by filtration, yield 85%.

 

参考资料

1、J. Am. Chem. Soc. 1979, 101, 1291–1293

2、Bulletin of the Chemical Society of Japan, 1981, 54, 793-799

3、Synthesis 1989, 949

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