用＂饥饿＂来治疗肿瘤? 一篇在顶级医学杂志发表的论文

近年来，有关肥胖和肿瘤的关系研究得越来越多。比如乳腺癌 http://blog.wenxuecity.com/myblog/69489/201612/1618849.html  ，肠癌，子宫内膜癌，以及最近的脂肪肝与肝癌的关系  http://blog.wenxuecity.com/myblog/69489/201702/22696.html?  等等。虽然还不够确定地说，肥胖是产生肿瘤的直接原因，但两者的相关性已足够引起重视。

有人尝试用改变饮食习惯和结构的方式来治疗癌症。这个方面的报道可谓是五花八门，更难定论。被提得很多的是一种叫做ketogenic diet，其理论根据是去除食物中的糖类，来＂饿死＂癌细胞。本人尚未有足够的精力和时间去深入了解这种方法，所以在这没有发言权。大家可以自己去摸索讨论。

那么肥胖和血液肿瘤有相关性吗? 在2007年发表在权威的《临床肿瘤杂志》Journal of Clinical Oncology 上，一组研究人员收集了从1988-1995年的343例肥胖，和3971例不肥胖的急性淋巴白血病患儿（ALL)。其结论是：肥胖影响到白血病患儿的复发和治愈率。

 

有趣的是，最近一群在德州（UT Southwestern Medical Center) 的华人学者，在顶级医学刋物巜Nature Medicine》上发表了一篇用饥饿(fasting)使血白细胞受到抑制的文章。

研究者制造了几个老鼠的急性白血病模型，来研究饮食对白血病细胞的影响。其＂惊喜＂结果在ALL(急性淋巴细胞性)白血病的模型中出现。

研究发现，间隙性一天禁食和一天进食，一共进行了六个周期后完全抑制了白血病的形成。七周后，禁食组检测不到血血病的形成(在试验的开始，这些老鼠都被注射了白血病细胞，七周后，先前注射的白血病细胞的行为像正常细胞一样)。而在对照的进食组68%的细胞是肿瘤细胞。禁食组的脾脏和淋巴结也没有肿大(ALL的常见临床表现)。进食组老鼠在59天之类便死亡，而在禁食组，75%的老鼠在120天后仍然存活，而且没有白血病发生。

看来，形势逼人，又多了一个与饮食/肥胖和肿瘤关系的模型！

http://blog.wenxuecity.com/myblog/69489/201612/1618849.html  

 http://blog.wenxuecity.com/myblog/69489/201702/22696.html? 

应该说，这个重大研究目前仅在动物模型阶段。在人体呢? 大家去推测吧。

Reference: 

1. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

• Zhigang Lu, Jingjing Xie, Guojin Wu, Jinhui Shen, Robert Collins, Weina Chen, Xunlei Kang, Min Luo, Yizhou Zou, Lily Jun-Shen Huang, James F Amatruda, Tamra Slone,Naomi Winick, Philipp E Scherer & Cheng Cheng Zhang

Nature Medicine 23, 79–90 (2017)doi:10.1038/nm.4252

 

2. Obesity and Outcome in Pediatric Acute Lymphoblastic Leukemia 

Anna M. Butturini, Frederick J. Dorey, Beverly J. Lange, David W. Henry, Paul S. Gaynon, Cecilia Fu, Janet Franklin, Stuart E. Siegel, Nita L. Seibel, Paul C. Rogers, Harland Sather, Michael Trigg,
W. Archie Bleyer, and William L. Carroll 

The 1988 to 1995 cohort included 343 obese and 3,971 nonobese patients. The 5-year event-free survival rate and risk of relapse,  in Conclusion : Obesity at diagnosis independently predicts likelihood of relapse and cure in preteenagers and adolescents with ALL. 

J Clin Oncol 25:2063-2069. © 2007 by American Society of Clinical Oncology 

[追梦]

长知识。谢谢！

[北美愚医]

回复 '泥中隐士' 的评论 : 你说的很有道理。毕竟动物实验和人体的差异太大了。

[泥中隐士]

截断肿瘤的营养不是新的想法。问题是怎样才能做到？靠吃一天饿一天？正常人一天得吃三顿饭，断一顿都饿的慌。还是想别的办法吧。

[北美愚医]

回复 '池上草堂' 的评论 : 非常感谢，很好的资料来源。

[北美愚医]

回复 'MoatCity' 的评论 : 谢谢你的评论

[北美愚医]

回复 'jyx-003' 的评论 : 我把原文复制过来：Strikingly, a regimen consisting of six cycles of 1 d of fasting, followed by 1 d of feeding,

[jyx-003]

什么是“间隙性一天禁食和一天进食，”？

[MoatCity]

Honestly how many fat centenarians have you seen? Almost all the people who lived above 100 years have been thin. Hiking with a Nurse Practitioner, started talking about Hep-C treatment, and how effective the new drugs are, she said that Hep-C is the major cause of liver transplant, now with the new drug, it won't be any longer. Then she asked me about the 2nd cause, I said Alcohol, she said NO, it is fatty liver.
Thanks for sharing, one more reason to keep the new year resolution of dropping weight, 2 LB so far, and 5 more pounds to go!

[池上草堂]

Many years ago, scientists believe sugar is the only source that cancer cell can use as energy. (To starve a tumor from MIT, http://news.mit.edu/2010/cancer-metabolism-0406). The reason behind ketogenic diet is to eliminate any kind of sugar intake.

Recently, MIT have two articles about how cancer cell can use other substance as energy. (How cancer cells get by on a starvation diet from MIT, http://news.mit.edu/2011/cancer-metabolism-1121; and How cancer cells fuel their growth from MIT, http://news.mit.edu/2016/how-cancer-cells-fuel-their-growth-0307).

According to this article, low calorie fasting does help to kill cancer cell (Fasting-like diet turns the immune system against cancer, http://news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/)

Hope this information helps.

[北美愚医]

发表的文章是真的。附上 References. Please refer to them.

[心戚然2]

真的，假的？