Department of Cell Biology
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115
Junying Yuan received her Ph.D. in Neuroscience from Harvard University in 1989 and her undergraduate degree from Fudan University, Shanghai, China, in 1982. Dr. Yuan carried out her Ph.D thesis work at the Massachusetts Institute of Technology. She was first appointed as Assistant Professor at Harvard Medical School in 1992, when she became a Principal Investigator of the Cardiovascular Research Center at Massachusetts General Hospital. She joined the Department of Cell Biology in 1996 and was appointed a Professor of Cell Biology at Harvard Medical School in 2000.
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Junying Yuan | |
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Born | Shanghai |
October 3, 1958
Nationality | American |
Fields | Biology Cell death |
Institutions | Harvard Medical School |
Alma mater | Fudan University Harvard University Massachusetts Institute of Technology |
Doctoral advisor | H. Robert Horvitz |
Known for | Apoptosis research Necroptosis |
Junying Yuan (Chinese: 袁钧瑛; pinyin: Yuán Jūnyīng, born October 3, 1958) is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School,[1] best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.[2][3] More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.[4]
Junying Yuan was born in Shanghai, where she attended Fudan University following the revival of higher education after its suspension under the Cultural Revolution. She was among the first wave of students to attempt the newly revived National Higher Education Entrance Examination in 1977, coming in first of all students who attempted it in Shanghai.[5] She completed her Bachelors in Biochemistry in 1982, and was subsequently one of the first students admitted to doctoral study in the United States through the China-U.S. Biochemistry Examination and Application (CUSBEA) program, coming in second out of the 25,000 who attempted the CUSBEA in its first year.[6]
In the United States, she completed her PhD in Neuroscience(1989) at Harvard University under the supervision of MIT professor H. Robert Horvitz, where she endeavored to elucidate the molecular mechanisms behind programmed cell death in the nematode Caenorhabditis elegans. She identified the proteins ced-3 and ced-4 as drivers behind programmed cell death in C. elegans, and subsequently identified the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1.[2][3][7]
Junying Yuan established an independent lab at Harvard-affiliated Massachusetts General Hospital in 1989, immediately upon completion of her PhD.[6] Her initial efforts were directed towards providing evidence for the functional role of caspases in mediating mammalian apoptosis.[8][9] Her independent work at this stage provided the first insights into molecular mechanisms in mammalian apoptosis, which contributed significantly to the Nobel Prize in Chemistry won by her PhD supervisor, Robert Horvitz.[10]
In 1996, Yuan moved her lab to the Department of Cell Biology at Harvard Medical School's Longwood campus, where she continued her investigation into cell death. Her work delved further into programmed cell death and revealed a wide cohort of proteins involved in the regulation and consequences of apoptosis. Some notable work includes her discovery that BID cleavage by caspase-8 mediates mitochondrial damage in apoptosis,[11] and her discovery of caspase-11's role in regulating caspase-1-driven inflammation.[12]
In 2005, Yuan's group discovered a non-apoptotic form of programmed necrotic cell death, which they termed "necroptosis".[4] Other groups first observed that the stimulation of Fas/TNFR family of death-domain receptors(DR) activated a canonical apoptotic pathway; however, in many cell types, not only did caspase inhibition fail to inhibit cell death, as would be expected of canonical apoptosis, but stimulated cells experienced a form of cell death that more closely resembled necrosis than apoptosis.[13] Yuan's group conducted a chemical screen that identified a small molecule capable of inhibiting DR-driven cell death, necrostatin-1, and demonstrated necroptosis' role in ischemic neuronal injury, thereby positing a potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1,[14] thus implicating it as a key player in necroptosis. Yuan went on to identify and characterize members of the signaling network responsible for regulating necroptosis,[15] and continues to elucidate the mechanisms of necroptosis while exploring its potential as a target of therapeutic intervention. Necrosis was previously considered to be a form of passive cell death, forced in response to stress. This belief had driven an aversion towards developing therapeutic applications targeting necrosis. In demonstrating a form of programmed necrosis, Yuan's work revealed new avenues of treatment for an ever-increasing cohort of diseases where necroptosis is implicated.[16]
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袁均英 博士 在 哈佛 做过 正教授吗?
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袁均英博士1982年毕业于复旦大学生化系,1989年获哈佛大学神经科学博士,师从H.R.Harvitz教授。1992年聘为哈佛医学院神经科学助理教授,1997年晋升为副教授,2000年起任哈佛大学医学院终生教授,
我的理解是哈佛医学院没有 真正的 tenured 的。要靠基金养自己的。
哈佛医学院成为正教授非常 困难,而且 正教授的工资还是要靠基金的。
有没有知道的人愿意解释一下?
一些地方解释袁博士是哈佛的正教授,大概基于 中国的 认识,大概认为 终身教授 肯定 正教授。
看 中国 现在的网站 比 资本主义 还要 资本主义。
http://www.erasmusmc.nl/radiologie/?lang=en
荷兰最大医学影像系的网站
https://strahlentherapie.charite.de
德国一大型肿瘤放疗科的网站
xxx xxx 课题组 xxx lab Yan lab 这样这样的东东 反正我只有在中国的网站 照片上看到过。公有财产怎么可以写上成 跟个人的一样
我看到颜宁的实验室显微镜 上 写着 Yan lab.
我觉得是难以想象的
1 是公共财产 还是 私人财产?
2 为什么不用 本国文字?
----- 非正式的网站:
http://tieba.baidu.com/p/3143876438
袁均英太厉害了 哈佛医学院的正教授啊!!
通宵看号007: 哈佛大学的正教授啊,世界一流啊。
Interdisciplinary Research Center on Biology and Chemistry
-- 这个名字语法有没有问题?