Start over-counter. Try products with salicylic acid (which removes the dead cells in clogged pores) or benzoyl peroxide (which kills the bacteria that cause acne). For oily skin, pick a gel with between 5 and 10 percent benzoyl peroxide, or try Clearasil Adult Acne Treatment Cream (which can get rid of dead skin cells)
Baby your skin. Use a gentle noncomedogenic moisturizer, like Aveeno Daily Moisturizing Lotion, to counter the drying efffects of pimple meds.
Don't overwash. Dirt doesn't cause zits, so cleaning face twice a day is enough.
Try to get some rest.
Get a prescription.