博文
SOP: How to Run an Atmospheric-Pressure Hydrogenation Reaction
(2022-05-21 07:12:37)
Hazards:Hydrogenationreactionsposeasignificantfirehazardduetotheuseofflammablereagentsandsolvents.Suchreagentsincludepalladiumoncarbon(Pd/C),whichishighlyflammableandcanignitesolventsandhydrogen.Itisespeciallydangerousafterhavingbeenusedforthehydrogenation.Thepresenceofhydrogengasincreasestheriskofexplosion.阅读全文]
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Do not pour any chemicals into the sink
(2022-05-21 07:11:12)
Donotpouranychemicalsintothesink.[阅读全文]
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TLC of amine
(2022-05-21 07:10:15)
ThebehaviourofaminsonTLCsometimeisweird.Evenonepurecompound,anaminecanshowmorethanonespotwhenaneutraleluentsystemisemployed.Inthissituation,abasiceluentsystembyaddingbasesuchammoniaortriethylaminewillredresstheproblem.[阅读全文]
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mCPBA
(2022-05-21 06:49:43)
nonereaction,mCPBAhasbeenusedforconvertingonealkenetooneepoxide.Afterthereaction,theexcessmeta-Chloroperoxybenzoicacidshouldnotbepouredintotheorganicwastebarrel.[阅读全文]
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Monitor One Reaction
(2022-05-21 06:48:46)
Formonitoronereaction,TLCshouldbethefirstconsideration.DonotrelayonNMRformonitoringonereaction.[阅读全文]
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More Haste, Less Speed
(2022-05-21 06:47:43)
Hastebringsnosuccess;hastemakeswaste;morehaste,lessspeed.[阅读全文]
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Don't Make Any Decision When You Are Angry.
(2022-05-21 06:46:16)
Don'tMakeAnyDecisionWhenYouAreAngry. [阅读全文]
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Quenching Reaction
(2022-05-21 06:45:33)
OnFridayoneaccidenttookplaceinmyworkduetomystupidmistake.Thereactionwasaboutepoxideringopeningbyusing3-pentanolasnucleophilicreagentcatalyzedbyborontrifluoride.Whenthereactionwascompleted,IstartedtoquenchingthereactionbyaddingaqueoussaturatedsodiumbicarbonatesolutiontothereactionRBF.Becausethesodiumbicarbonatesolutionwasaddedtoofast,lotsoffoamwasgeneratedduetotheformationofcarbondioxidefromsodiumb...[阅读全文]
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Reaction Including Metal Reagent
(2022-05-20 16:40:37)
Reactionincludingmetalreagentusuallygenerateheatandgas!Becareful!LastFridayIhadrunonereactionwhichisaboutthe1,4-Additionof1,3-DiesterstoConjugatedEnonesbyIn/TMSCl.WhenindiumwasaddedtoTHF,nothingtooksplacebutjustleadingtoonesuspension.Whendiethylbromomalonatewasadded,stillnothinghappened.However,whenTMSClwasaddedtotheabovemixture,hugeamountofheatandgaseswereproduced.Sothereactionmixturejustoverflow...[阅读全文]
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Working Up Reaction
(2022-05-20 16:39:38)
TodayIhadrunonereaction:nitrosationofdiphenylamine.TlCshowsthereactionworksprettywellandnostartingmaterialsexists.Becausetheproductisoneprecipitate.SoItrytogettheproductbyfiltration.BecausethereisstillproductintheRBFafterthedumping,ItrytowashthereactionRBFusingthefiltratetogetahighyield.HoweverIforgetatthistimethetemperatureofthefiltrateishigherthatthereactiontemperatureof5degree.Becauseofthis,som...[阅读全文]
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