TheBurgessreagent(methylN-(triethylammoniumsulfonyl)carbamate)isamildandselectivedehydratingreagentoftenusedinorganicchemistry.ItwasdevelopedinthelaboratoryofEdwardM.BurgessatGeorgiaTech.TheBurgessreagentisusedtoconvertsecondaryandtertiaryalcoholswithanadjacentprotonintoalkenes.Dehydrationofprimaryalcoholsdoesnotworkwell.Thereagentissolubleincommonorganicsolventsandalcoholdehydrationtakesplacewith...[
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“替罪羊”源于《圣经》的《旧约》，有一个非常有趣的小典故。在摩西时代，依据法规，犹太人在新年过后的第10天，还有一个非常重要的节日Atonement/YomKippur（赎罪日）。在这一天，犹太人彻底斋戒，并在圣殿举行祭祀仪式，以此祈求上帝赦免他们在过去一年中所犯的罪过。祭祀时，教徒们拿来两头山羊，一头为theLord'sgoat（“献给上帝的羊”，不言而喻，小[
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提起保护基化学，什么Boc，Cbz，Fmoc，Alloc，TFAA等等立刻涌入脑海，这些都是胺的保护基。相较于胺基保护，羧酸很多时候也需要保护。常见的羧酸保护基有叔丁酯，甲酯，乙酯，苄酯，烯丙醇酯，还有三氯乙醇酯等等。叔丁酯用酸脱保护，甲酯/乙酯一般用碱脱保护，苄酯一般用氢解脱保护，烯丙醇酯可以用四三苯基膦钯搭配亲核试剂脱保护，三氯乙醇酯可以用锌粉搭配氯化铵[
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结晶和重结晶详细操作步骤
1.将需要纯化的化学试剂溶解于沸腾或将进沸腾的适宜溶剂中；
2.将热溶液趁热抽滤，以除去不溶的杂质；
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ThePictet–Spenglerreactionisachemicalreactioninwhichaβ-arylethylamineundergoescondensationwithanaldehydeorketonefollowedbyringclosure.Thereactionwasfirstdiscoveredin1911byAméPictetandTheodorSpengler(February22,1886-August18,1965).Traditionallyanacidiccatalystinproticsolventwasemployedwithheating,howeverthereactionhasbeenshowntoworkinaproticmediainsuperioryieldsandsometimeswithout...[
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TheBischler–Napieralskireactionisanintramolecularelectrophilicaromaticsubstitutionreactionthatallowsforthecyclizationofβ-arylethylamidesorβ-arylethylcarbamates.Itwasfirstdiscoveredin1893byAugustBischlerandBernardNapieralski,inaffiliationwithBasleChemicalWorksandtheUniversityofZurich.Thereactionismostnotablyusedinthesynthesisofdihydroisoquinolines,whichcanbesubsequentlyoxidizedtoiso...[
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TheDuffreactionorhexaminearomaticformylationisaformylationreactionusedinorganicchemistryforthesynthesisofbenzaldehydeswithhexamineastheformylcarbonsource.ItisnamedafterJamesCooperDuff,whowasachemistattheCollegeofTechnology,Birmingham,around1920–1950.TheelectrophilicspeciesinthiselectrophilicaromaticsubstitutionreactionistheiminiumionCH2+NR2.Theinitialreactionproductisaniminiumwhichishydrolyz...[
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Silicon-basedprotectinggroupsarecommonplaceinsyntheticroutestocomplexorganicmolecules.Theirabilitytobeintroducedundermildconditions,aswellastheirstabilitytowardharshreactionconditions,hasmadethemawidespreadtoolinorganicsynthesis.Smallsilylprotectinggroups,suchasthetrimethylsilylgroup,canberemovedunderbasicoracidicconditions,butlargersilylprotectinggroupsaregenerallyremovedunderfluoride-mediatedcon...[
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