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N-tosyliminobenzyliodinane - PhINTs from Iodobenzene diacetate
(2024-12-26 10:43:59)

Chemicals p-Toluenesulphonamide(Aldrich)阅读全文]
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Chloramine-T
(2024-12-26 10:29:18)
Chloramine-TistheorganiccompoundwiththeformulaCH3C6H4SO2NClNa.Boththeanhydroussaltanditstrihydrateareknown.Botharewhitepowders.Chloramine-Tisusedasareagentinorganicsynthesis.[2]Itiscommonlyusedascyclizingagentinthesynthesisofaziridine,oxadiazole,isoxazoleandpyrazoles.[3]It'sinexpensive,haslowtoxicityandactsasaoxidizingagent.Inaddition,italsoactsasasourceofnitrogenanionsandelectrophiliccations....[阅读全文]
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Benzyl chloroformate
(2024-12-26 10:09:39)

Benzylchloroformate,alsoknownasbenzylchlorocarbonateorZ-chloride,isthebenzylesterofchloroformicacid.Itcanbealsodescribedasthechlorideofthebenzyloxycarbonyl(CbzorZ)group.Initspureformitisawater-sensitiveoilycolorlessliquid,althoughimpuresamplesusuallyappearyellow.Itpossessesacharacteristicpungentodoranddegradesincontactwithwater. ThecompoundwasfirstpreparedbyLeonidasZervasintheearly1930swhousedi...[阅读全文]
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Hydrogen peroxide urea adduct, UHP
(2024-12-26 09:55:12)

Urea-hydrogenperoxideisanon-toxic,odorlesscrystallinesolid.Thisadduct,whichcontains35%ofH2O2,setsthehydrogenperoxidefreeduringitsapplication. Urea-hydrogenperoxideinthepresenceofacatalyticamountofmagnesiumbromideefficientlyoxidizesprimaryandsecondarybenzylicalcoholsintothecorrespondingaromaticaldehydesandketones. [阅读全文]
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nicolaou oxidation
(2024-12-26 08:57:27)

o-Iodoxybenzoicacid(IBX)wasfoundtobehighlyeffectiveinoxidationsadjacenttocarbonylandbenzylicfunctionalitiestoformeitherα,β-unsaturatedcarbonylcompoundsorconjugatedaromaticcarbonylsystems.Fine-tuningofthereactionconditionsallowedremarkablyselectivetransformationswithinmultifunctionalsubstrates. [阅读全文]
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Davis Oxidation
(2024-12-26 08:30:12)

Theuseof2-(phenylsulfonyl)-3-phenyloxaziridine(Davisreagent)orsimilaroxaziridinereagentsenablesanoxidationofenolatesgeneratedinsitufromketonesoresterstoprovideα-hydroxylatedcompounds. MechanismoftheDavisOxidation ThetransferofoxygenfromN-sulfonyloxaziridinestonucleophileshappensinaSN2mechanism,inwhichtheenolateanionasnucleophileattackstheoxaziridineoxygenatomtogiveahemiaminal...[阅读全文]
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DMF-DMA
(2024-12-25 19:30:23)

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Kharasch–Sosnovsky reaction
(2024-12-25 17:58:32)

TheKharasch–Sosnovskyreactionisamethodthatinvolvesusingacopperorcobaltsaltasacatalysttooxidizeolefinsattheallylicposition,subsequentlycondensingaperoxyester(e.g.tert-Butylperoxybenzoate)oraperoxideresultingintheformationofallylicbenzoatesoralcoholsviaradicaloxidation.[1]Thismethodisnoteworthyforbeingthefirstallylicfunctionalizationtoutilizefirst-rowtransitionmetalsandhasfoundnumerousapplicat...[阅读全文]
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Dimethyldioxirane
(2024-12-24 21:01:18)

Dimethyldioxirane(DMDO)istheorganiccompoundwiththeformula(CH3)2CO2.[1]Itisthedioxiranederivedfromacetoneandcanbeviewedasthemonomerofacetoneperoxide.Itisapowerfulselectiveoxidizingagentthatfindssomeuseinorganicsynthesis.Itisknownonlyintheformofadilutesolution,usuallyinacetone,andhencethepropertiesofthepurematerialarelargelyunknown.[2] DMDOisnotcommerciallyavailablebecauseofchemicalinstability.DM...[阅读全文]
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Coupling Reagents
(2024-09-22 17:59:33)

Carbodiimide(DCC,DIC,EDCHCl) Dicyclohexylcarbodiimide(DCC)anddiisopropylcarbodiimide(DIC)arecommonlyusedtoprepareamides,estersandacidanhydridesfromcarboxylicacids.Thesereagentscanalsoconvertprimaryamidestonitriles,whichcanbeusefulinorganicsynthesisbutisatroublesomesidereactionofasparagineandglutamineresiduesinpeptidesynthesis.Dicyclohexylurea,thebyproductformedfromDCC,isnearlyinsolubleinmostorg...[阅读全文]
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