OrganicRoute有机合成路线2023-07-1720:35钯碳或铂碳广泛应用于不饱和键（双键或炔键）或硝基类化合物的还原，相对于金属还原剂（锌粉或铁粉），其后处理更为简单。当底物中含有I，Br，Cl的时候，这个时候还原底物中的官能团的时候，如果使用钯碳或铂碳方法，有脱卤素的风险，这个时候我们往往会求助于锌粉或铁粉，PtO2，或Wilkinson等还原或催化还原体系。钯碳氢化还原体系[阅读全文]
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(2023-07-17 20:31:30)
OrganicRoute有机合成路线2023-07-1720:35钯碳或铂碳广泛应用于不饱和键（双键或炔键）或硝基类化合物的还原，相对于金属还原剂（锌粉或铁粉），其后处理更为简单。当底物中含有I，Br，Cl的时候，这个时候还原底物中的官能团的时候，如果使用钯碳或铂碳方法，有脱卤素的风险，这个时候我们往往会求助于锌粉或铁粉，PtO2，或Wilkinson等还原或催化还原体系。钯碳氢化还原体系[阅读全文]
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SkellysolveAisessentiallyn-pentane,b28-30°/atm,阅读全文]
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(2023-07-07 21:36:43)
PACKINGACOLUMNSimplestepstoclarifyasamplebeforeapplyingittoacolumnwillavoidtheriskofblockage,reducetheneedforstringentwashingproceduresandextendthelifeofthechromatographymedium.Filterorcentrifugeallsolventsandsamplesbeforeuse. RefertoTable6.4tocalculatetheamountofdrymediumrequiredastheextentofswellingdependsuponthesolventsystem.SwellSephadex®LH-20foratleast3hatroomtemperatureinthesolventtobeus...[阅读全文]
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HP-20isapolymericreversephase,soitwillbehaveprettymuchlikeC18intermsofaseparationmechanism.Startwithwater,andrunagradientwithmethanolorethanolasdescribedabove.Onecanuseacids(trifluoro,formic,oraceticacid)ifneededtosharpenpeaks.Forloadingthesample,soundslikeyoursampleissolubleinwatersoaliquidloadisappropriate. [阅读全文]
(2023-07-02 15:18:02)
Youwillknowintheorythatmostelementsnaturallyexistasmixturesofisotopes.Ifyoudidn’tbelieveit,nowyouwill.Chlorineisnormallya3:1mixtureof35Cland37Cl(hencetheobviouslyfalserelativeatomicmassof‘35.5’forchlorine)whilebromineisanalmost1:1mixtureof79Brand81Br(hencethe‘average’massof80forbromine!).Massspectrometryseparatestheseisotopessothatyougettruenotaveragemolecularweights....[阅读全文]
