化学酷2023-08-2119:30氟被称为“asmallatomwithabigego”，是元素周期表中电负性最大的元素，其与碳形成的C-F键比碳与其它元素形成的单键都要强，因而C-F键很难断裂，更重要的是，在有机分子中引入氟原子或含氟取代基常常会引起其物理、化学性质以及药理生理活性的改变，这使得含氟化合物在医药、农药及功能材料等领域的应用备受关注。但是，尽管氟在地壳中含量丰富（[阅读全文]
博文
(2023-08-24 19:05:21)
化学酷2023-08-2119:30氟被称为“asmallatomwithabigego”，是元素周期表中电负性最大的元素，其与碳形成的C-F键比碳与其它元素形成的单键都要强，因而C-F键很难断裂，更重要的是，在有机分子中引入氟原子或含氟取代基常常会引起其物理、化学性质以及药理生理活性的改变，这使得含氟化合物在医药、农药及功能材料等领域的应用备受关注。但是，尽管氟在地壳中含量丰富（[阅读全文]
(2023-08-16 19:03:26)
MeSO2ClTheformationofmesylateswithmethanesulfonylchloride(MeSO2Cl)isusuallyaccomplishedwithabase(ex.TEAorpyridine),inasolventsuchasDCM,withcoolingoratRT.Apossibleside-pdtisthecorrespondingalkylchloride(seeAlcoholtoChloride-SulfonylChlorides).Example1ToasolutionoftheSM(300mg,2.30mmol)inDCM(6mL)at0CwasaddedTEA(0.64mL,4.6mmol)followedbyMeSO2Cl(0.21mL,2.76mmol).Thereactionmixturewasstirredat0Cfor30min...[阅读全文]
(2023-08-16 18:14:46)
(2023-08-16 17:20:06)
(2023-08-14 20:17:51)
DAST(DiethylaminosulfurTrifluoride)OtherNames:N,N-Diethylaminosulfurtrifluoride(Diethylamino)sulfurtrifluorideDiethyl(trifluorosulfido)amineStructure:CASNumber:38078-09-0MolecularWeight:161.19g/molAppearance:ColorlessoilBoilingPoint:30-32Cat3mmHgDensity:1.22g/mLDiethylaminosulfurtrifluoride(DAST)isanucleophilicfluorinatingagentwithwideuseinorganicchemistry.Deoxo-Fluorismorethermallystablealternati...[阅读全文]
(2023-08-14 17:22:06)
TransesterificationistheprocessofexchangingtheorganicfunctionalgroupR″ofanesterwiththeorganicgroupR'ofanalcohol.Thesereactionsareoftencatalyzedbytheadditionofanacidorbasecatalyst.Thereactioncanalsobeaccomplishedwiththehelpofotherenzymes,particularlylipases(oneexampleisthelipaseE.C.3.1.1.3). Strongacidscatalysethereactionbydonatingaprotontothecarbonylgroup,thusmakingitamorepotentel...[阅读全文]
(2023-08-12 05:40:10)
Theweigelaflorida'RedPrince'genuswasnamedinhonoroftheGermanscientist,ChristianWeigel.AnancientspeciesfromAsia,fossilevidencesuggeststheseplantshavebeenpresentformillionsofyears,althoughtheydidnotreachEuropeuntilthe19thcentury.Thishardyplantperformsbestwheninfullsun.Thetube-shapedflowersaretheperfectfitforhummingbirdsandthesweetnectarattractsahostofotherpollinators. Theweigelaflorida'...[阅读全文]
(2023-08-11 19:04:02)
Peegeehydrangea(Hydrangeapaniculata'Grandiflora'),oftenwrittenaspeegee,isaparticularlycold-hardyhydrangeavariety.Thisshrub'sbloomsformlargecone-shapedclusters(panicles)ofwhiteflowersthatdevelopapinkorpurpletintovertime.PeegeehydrangeaishardyinUSDAZones3through8,makingitagreatshrubselectionforlandscapesincoldclimateswhereothertypesofhydrangeaswon'tgrowsuccessfully.Peegeehydrangeasar...[阅读全文]
(2023-08-07 21:20:43)
PatDussault,UniversityofNebraska-Lincolnpdussault1@unl.eduAugust1,201IntroductionandleadingreferencesThefollowingprovidesabriefintroductiontotheapplicationofozonolysiswithinacademiclabs.Ozonolysisremainsamongthemostfrequentlyusedofmethodsforoxidativecleavageofalkenes.Whilebestknownasameansbywhichtointroducealdehydesandketones,ozonolysiscanalsobeusedtogenerateotherfunctionalgroups.Anoverviewofsomeo...[阅读全文]
(2023-08-04 19:32:24)
OrganicRoute有机合成路线2023-07-2409:45甲基以及烷基（杂）芳香类化合物苄位上溴反应可以说是有机合成化学中最常见的反应类型之一了，反应属于自由基类型，反应生成的苄溴类合成砌块，在医药研发中应用非常广泛，可以与各种亲核试剂反应，像叠氮化钠，胺类，苯酚类，硫醇类等等。这类反应通常使用卤代溶剂，用的最多的是四氯化碳和二氯甲烷，引发剂一般使用BPO(Benzoylper[阅读全文]
