Like others before him, the strain of being in charge of the world's most powerful nation will no doubt leave its legacy in a trail of lines and wrinkles.
During his campaign, the 47-year-old admitted he was getting more grey hair, joking: 'Running for president will age you quick.'
He has only to look at Tony Blair, who wrinkled and greyed noticeably during his years as prime minister.
Doctors say stress can fuel ageing as it triggers the release of hormones and adrenaline, causenig blood vessels to constrict.
This causes malnutrition of the skin, starving it of oxygen. However, since stepping down last year, Mr Blair seems rejuvenated.
Smoking and lack of sleep can also show in the skin, although Mr Obama has just quit his four-a-day cigarette habit.
But with a new job and a young family, he is unlikely to get as much sleep as his predecessor George Bush - who insists on going to bed by 9.30pm.