After reading biochemical science here and there and some psycology books, I start to think there is a biochemical base for people's personality. After the first google try, I actually find something with the exact name "Biochemical Personality". They are related to drug or alcohol abuse.
http://www.narcononrehab.com/english/Narconon_Program.html
Long-term alcoholism and drug addiction can cause one's personality to change. This is called the Biochemical Personality. Some of the characteristics are:
Addicts cannot stop using drugs for two reasons. These are: