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Syringe Filters
(2022-05-21 07:23:54)

当酸水解然后用阴离子交换树脂中和。最终产品通过烧结漏斗过滤蒸除溶剂拿到。结果发现产品中有不溶于水的固体颗粒。固体颗粒应该来自于树脂。所以过滤时用膜过滤应该比较好。 [阅读全文]
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Hydrogenation
(2022-05-21 07:14:34)
Palladiumoncarbon(Pd/C)frequentlyigniteswhenitfirstcomesincontactwithmethanol(andtoalesserextent,anyflammableorganicsolvent)andassuchrepresentsasignificantsafetyrisk.TheseproceduresarerecommendedwheneverPd/Cisusedinconjunctionwithhydrogengas. Hydrogenationusingaballoon: 1)Evacuatethereactionvessel(thisshouldhaveatleasttwoopenings)andbackfillwithaninertgas(nitrogenorargo...[阅读全文]
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SOP: How to Run an Atmospheric-Pressure Hydrogenation Reaction
(2022-05-21 07:12:37)
Hazards:Hydrogenationreactionsposeasignificantfirehazardduetotheuseofflammablereagentsandsolvents.Suchreagentsincludepalladiumoncarbon(Pd/C),whichishighlyflammableandcanignitesolventsandhydrogen.Itisespeciallydangerousafterhavingbeenusedforthehydrogenation.Thepresenceofhydrogengasincreasestheriskofexplosion.阅读全文]
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Do not pour any chemicals into the sink
(2022-05-21 07:11:12)
Donotpouranychemicalsintothesink.[阅读全文]
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TLC of amine
(2022-05-21 07:10:15)
ThebehaviourofaminsonTLCsometimeisweird.Evenonepurecompound,anaminecanshowmorethanonespotwhenaneutraleluentsystemisemployed.Inthissituation,abasiceluentsystembyaddingbasesuchammoniaortriethylaminewillredresstheproblem.[阅读全文]
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mCPBA
(2022-05-21 06:49:43)
nonereaction,mCPBAhasbeenusedforconvertingonealkenetooneepoxide.Afterthereaction,theexcessmeta-Chloroperoxybenzoicacidshouldnotbepouredintotheorganicwastebarrel.[阅读全文]
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Monitor One Reaction
(2022-05-21 06:48:46)
Formonitoronereaction,TLCshouldbethefirstconsideration.DonotrelayonNMRformonitoringonereaction.[阅读全文]
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More Haste, Less Speed
(2022-05-21 06:47:43)
Hastebringsnosuccess;hastemakeswaste;morehaste,lessspeed.[阅读全文]
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Don't Make Any Decision When You Are Angry.
(2022-05-21 06:46:16)
Don'tMakeAnyDecisionWhenYouAreAngry. [阅读全文]
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Quenching Reaction
(2022-05-21 06:45:33)
OnFridayoneaccidenttookplaceinmyworkduetomystupidmistake.Thereactionwasaboutepoxideringopeningbyusing3-pentanolasnucleophilicreagentcatalyzedbyborontrifluoride.Whenthereactionwascompleted,IstartedtoquenchingthereactionbyaddingaqueoussaturatedsodiumbicarbonatesolutiontothereactionRBF.Becausethesodiumbicarbonatesolutionwasaddedtoofast,lotsoffoamwasgeneratedduetotheformationofcarbondioxidefromsodiumb...[阅读全文]
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