谢维院长 福耀科技大学生命与健康科学学院

谢维院长 福耀科技大学生命与健康科学学院

https://lhs.fyust.edu.cn/szdw/jstd/xw.htm?

研究方向：突触/环路发育调控与认知疾病机制

Email：[e-mail]

个人简历

1963年9月出生，安徽人，博士毕业于南京大学生物化学与分子生物学专业，1996年12月至2001年8月先后在美国罗彻斯特大学医学中心和加拿大多伦多大学附属病童医院（SickKids）接受博士后训练。2001年9月作为教育部“长江学者”特聘教授，受聘为东南大学基础医学院遗传学研究中心主任，担任博士生导师；领衔申报东南大学第一个生命科学领域博士授权点（遗传学）获准；2003年获准建设“发育与疾病相关基因”教育部重点实验室，担任实验室主任；2004年4月至2009年11月担任东南大学基础医学院院长，2009年12月至2019年12月担任东南大学生命科学研究院院长，期间完成了东南大学生物学一级学科硕士点、博士点、博士后流动站的建设、协助基础医学博士点的获准；2019年领衔论证成立生命科学与技术学院，获得东南大学批准，谢维任学院学术委员会主任、东南大学首席教授。

谢维教授先后获得国家自然科学基金（面上、重点）、中-加合作项目、国家杰出青年科学基金（2003年）、美国NIH基金（RO3）、国家“973”重大基础研究项目、国家科技创新2030-“脑科学与类脑研究”（“国家脑计划”）重大研究项目（首席科学家）等资助。长期从事脑发育的遗传控制、跨细胞与跨系统信号调节机制和抗体工程靶向药的研究。发现了自闭症关联基因参与调控突触、环路发育；解析了调控社交行为的多条神经环路等；指导创业团队研发抗体靶向药，已获得临床试验许可证6张（中、美），其中两款药物分别在临床I、II期实验。

1992年9月-1995年10月

南京大学 生化与分子生物学 研究生 博士

1988年9月-1991年7月

南京铁道医学院（现东南大学医学院） 微生物与免疫学 研究生 硕士

发表的文章

1... Dandan Lv, An Liu*, Ziyue Yi, Mingdao Mu, Miao Wu, Xingcan Li, Kun Cao, Ruining Liu, Zhengping Jia, Junhai Han, Wei Xie*. Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons. Adv Science (Weinh). 2025 Feb;12(5):e2410728.摘要

限制性和重复性行为（RRB）是自闭症谱系障碍（ASD）的主要症状之一，对个体健康构成重大风险，且患病率日益上升。然而，RRB产生的具体细胞和神经环路机制尚不清楚。本研究发现，背侧纹状体中表达多巴胺受体D2的中型棘状神经元（D2-MSN）中ASD相关蛋白神经连接蛋白1（NLGN1）的缺失与自我梳理和挖掘行为的持续时间和频率相关。NLGN1缺陷的D2-MSN处于过度激活状态，这与过度自我梳理和挖掘行为相关。抑制D2-MSN的活性可以减少这些RRB的持续时间和频率。此外，研究还表明，自我梳理和挖掘行为的产生依赖于D2-MSN不同的活性模式。最后，通过单核RNA测序（sn-RNAseq）和蛋白质检测验证，发现Nlgn1缺陷小鼠中蛋白激酶C（PKC）的过度激活导致了过度重复行为和神经元兴奋性增强。本研究提出了自我梳理和挖掘行为产生的潜在机制，并提出了自闭症谱系障碍（ASD）可能的治疗和干预措施。

2... Peng Xie, Juan Shen, Yi Yang, Xinrui Wang, Wei Liu, Hailong Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, Jingjing He, Weiheng Zheng, Zepu Yang, Xiao Zhang, Xu Jiang, Xianfa Yang, Ke Fang, Zhao Zhang, Xin Xue, Xueting Chen, Chaoyi Wang, Xing Liu, Ling Liu, Xuebiao Yao, Naihe Jing, Wei Xie, Jin Liu, Hua Cao, Zhuojuan Luo*, Xiaodong Fang*, Chengqi Lin*. Digital reconstruction of full embryos during early mouse organogenesis. Cell, 2025, 188, 1-19.

小鼠早期器官发生过程中完整胚胎的数字化重建

亮点  在早期器官发生过程中，以单细胞分辨率重建完整数字胚胎, 构建中胚层和内胚层谱系的时空图谱和信号通路图谱, 识别胚-胚外界面处的原基决定区 (PDZ), 表征参与器官原基形成的跨胚层信号

总结  早期器官发生是胚胎发育的关键阶段，其特点是广泛的细胞命运决定以启动器官形成，但也极易出现发育缺陷。在此，我们对来自 6 个 E7.5-E8.0 胚胎的 285 个连续切片进行了分析，以单细胞分辨率构建了早期器官发生过程中的完整时空转录组和信号通路图谱。通过开发 SEU-3D，我们重建了数字胚胎，从而能够在天然的空间环境中研究区域化的基因表达。我们建立了一种基于空间信息的基因-细胞共嵌入方法，系统地构建了内胚层和中胚层衍生物的空间图谱，并阐明了跨胚层和细胞类型的信号网络。此外，我们还表征了在胚胎发育第7.75天（E7.75）沿胚胎-胚外界面形成的原基决定区（PDZ），并揭示了协调的信号通讯促进了心脏原基的形成。总而言之，这种高分辨率的“数字胚胎”为早期器官发生提供了重要的见解，并为研究发育和疾病提供了一个独特的空间平台。

3. Shiqi Zhu, Peng Xie, Yi Yang, Yan Wang, Chuanxin Zhang, Yu Zhang, Shuhan Si, Jin Zhang, Jingjing He, Hao Si, Ke Fang, Binbin Ma, Xu Jiang, Lindi Huang, Jiamin Li, Tian Min, Beihong Zheng, Lincui Da, Dianliang Lin, Kun Gao, Yuanyuan Li, Mingtao Huang, Fengchang Qiao, Haiqin Huo, Haoyang Feng, Han Zhao, Zijiang Chen, Zhengfeng Xu, Jing Xie, Hua Cao, Jin Liu, Xuebiao Yao, Wei Xie, Yan Sun, Keliang Wu, Bo Xiong, Ping Hu*, Zhuojuan Luo*, Chengqi Lin*. Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage. Nat Struct Mol Biol. 2025 Feb;32(2):381-392.

4... Yu Zhao, Junhua Geng*, Zhu Meng, Yichen Sun, Mengzhu Ou, Lizhong Xu, Moyi Li, Guangming Gan, Menglong Rui, Junhai Han, Wei Xie*. Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function in Drosophila. Commun Biol. 2024, Nov. 9; 7:1481.

1. Rui Dang, An Liu*, Yu Zhou, Xingcan Li, Miao Wu,Kun Cao,Yanghong Meng, Haiwang Zhang, Guangming Gan, Wei Xie* & Zhengping Jia*. Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice. Nat Commun 2024, 15, 8639.

2. Mingdao Mu*, Haoyu Sun, Shuyan Geng, Tianxiang Xu, Chuanyao Sun, Zixu Zhang, Sibie Meng, Moyi Li, An Liu, Zhiyuan Yang and Wei Xie*. Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake. Mol Brain, 2024, 17:49.

3. Haiyan Sun*, Yu Shen, Pengtao Ni, Xin Liu, Yan Li, Zhentong Qiu, Jiawen Su, Yihan Wang, Miao Wu, Xiangxi Kong, Jun-Li Cao*, Wei Xie*, and Shuming An*. Autism-associated neuroligin-3 deficiency in medial septum causes social deficits and sleep loss in mice. J Clin Invest. 2024 Jul 25:e176770.

4. Siqi Peng, Xiuqi Yang, Sibie Meng, Fuyuan Liu, Yaochen Lv, Huiquan Yang, Youyong Kong, Wei Xie, Moyi Li*. Dual circuits from hippocampus facilitate naive social 2 transfer of observational fear. Cell Reports, 2024 May 27;43(6):114277.

5. Qiaoyun Ren, Susu Wang, Junru Li, Kun Cao, Mei Zhuang, Miao Wu, Junhua Geng, Zhengping Jia, Wei Xie, An Liu*. Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating α-secretase. J Neurosci. 2024 Feb 28:e1689232024. (This Week in The Journal)

6. Siyan Meng, Xiaoxu Liu, Shiqi Zhu, Peng Xie, Haitong Fang, Qingyun Pan, Ke Fang, Fanfan Li, Jin Zhang, Zhuanzhuan Che, Quanyong Zhang, Guangyao Mao, Yan Wang, Ping Hu, Kai Chen, Fei Sun, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Sep;25(9):1319-1331.

7. Yichen Sun, Moyi Li*, Junhua Geng, Sibie Meng, Renjun Tu, Yan Zhuang, Mingkuan Sun, Menglong Rui, Mengzhu Ou，Guangling Xing, Travis K Johnson, Wei Xie*. Neuroligin 2 Governs Synaptic Morphology and Function Through RACK1-Cofilin Signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056.

8. Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Wei Xie, Lijuan Liu, Liwei Zhang*, Hanchuan Peng*. Whole Human-Brain Mapping of Single Cortical Neurons for Profiling Morphological Diversity and Stereotypy. Science Adv, 2023, 9(41): eadf3771.

9. Rui Dang, Yu Zhou, Yue Zhang, Die Liu, Miao Wu, An Liu, Zhengping Jia* & Wei Xie*. Regulation of Social Memory by Lateral Entorhinal Cortical Projection to Dorsal Hippocampal CA2. Neurosci Bull, 2022 https://doi.org/10.1007/ s12264-021-00813-6.

10. Hanchuan Peng*, Peng Xie,#, Lijuan Liu#, Yimin Wang, Lei Qu, Hui Gong, Xiuli Kuang, Shengdian Jiang, Anan Li, Zongcai Ruan, Liya Ding, Mengya Chen, Tanya L. Daigle, Zhangcan Ding, Yanjun Duan, Aaron Feiner, Ping He, Chris Hill, Karla E. Hirokawa, Guodong Hong, Lei Huang, Sara Kebede, Hsien-Chi Kuo, Rachael Larsen, Phil Lesnar, Longfei Li, Qi Li, Xiangning Li, Yaoyao Li, Yuanyuan Li, An Liu, et al, Yefeng Zheng, Zhongze Gu, Wei Xie, Christof Koch, Qingming Luo, Julie A. Harris, Yun Wang, Hongkui Zeng*. Complete whole-brain single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types. Nature, 2021, 598:174-181.

11. Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Han*. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, 2021, 81:1425-1438.

12. Wei Xie*, Cheng-Qi Lin, Jian Li, Mo-Yi Li. Decoding brain encoded by genome. Yi Chuan (Hereditas Beijing), 2021 May 20;43(5):393-396.

13. Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie*. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proc Natl Acad Sci U S A. 2020,117(10): 5472-5477.

14. Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie*. Rapid Delivery of Nanobodies/ VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Mol Therapy - Methods & Clinical Development, 2020, 17:401-408.

15. Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, DOI: 10.7554/eLife.30457.

16. Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L. Collingridge*, Zhengping Jia*. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nat Neurosci, 2018, 21(1):50-62.

17.  Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. BBA-General, 2018, 1862(3):440-450.

18. Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction. J Biol Chem, 2017, 292(44):17991-18005.

19. Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia and Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. J Biol Chem, 2017, 292(35):14334-14348.

20. Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. JMCB, 2017, 9(3):231-242.

21. Lina Liu, Yao Tian, Xiaoyan Zhang, Xinwang Zhang, Tao Li, Wei Xie, and Junhai Han*. Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering. Deve Cell, 2017, 41:94-106. (Cover Story)

22. Yan Wang, Yang Shen, Qian Yang, Qian Dai, Yue Zhang, Xin Wang, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Nucleic Acids Res, 2017, 45(3):1177-1185.

23. Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, and Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

24. An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, and Wei Xie*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. J Cell Biol, 2016, 212:449-463. (Cover Story, w/COMMENTARY)

25. Tao Li, Yao Tan, Qian Li, Huiying Chen, Huihui Lv, Wei Xie, and Junhai Han*. Neurexin/NSF interaction regulates short-term synaptic depression. J Biol Chem 2015, 290(29):17656-67. (Papers of the Week, Cover Story, 2015 Best of Winner)

26. Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Mol Brain, 2015, 8:36.

27. Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. J Biol Chem, 2014, 289(46): 31867-31877. (Paper of the Week)

28. Yi Li, Ziaki Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zi chao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci, 2013, 33:15545-15554.

29. Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 140:413-422.

30. SUN MingKuan*, XIE Wei*. Cell Adhesion Molecules in Drosophila Synapse Development and Function. Sci China Life Sci, 2012, 55(1):20-26.

31. David Knight, Wei Xie and Gabrielle Boulianne*. Neurexins and Neuroligins: Recent Insights from Invertebrates. Mol Neurobiol, 2011, 44(3):426-440.

32. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. J Neurosci, 2011, 31(2):687-699. (This Week in The Journal)

33. Mingkuan Sun, Lijuan Liu Xiankun Zeng, Li Liu, Ming fang, Wei Xie*. Genetic Interaction between Neurexin and CAKI/CMG Is Important for the Synaptic Function in Drosophila Neuromuscular Junction. Neurosci Res, 2009, 64:362-71.

34. Xiankun Zeng, Mingkuan Sun, Li Liu, Fading Chen, Liuchan Wei, Wei Xie*. Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett, 2007,581:2509-2516.