认真讨论与认知有关的染色体和基因

不好意思，其实俺只是认真的问了下chatGPT，没有认真去查每一篇文章， 但是貌似偏差不大啊，如有偏差，也是chatGPT的错 

下面是内容(英文在前，中文在后)，大家自己看，俺不做任何评价 LOL

Chromosome 1

• DISC1 (Disrupted in Schizophrenia 1): Associated with cognitive performance and brain development.
  • Reference: Thomson, P.A., et al. "DISC1 Genetics, Cognition and Psychopathology." Molecular Psychiatry, 2013.

Chromosome 2

• NRG1 (Neuregulin 1): Linked to cognitive function and schizophrenia.
  • Reference: Stefansson, H., et al. "Neuregulin 1 and Susceptibility to Schizophrenia." American Journal of Human Genetics, 2002.

Chromosome 3

• CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit): Associated with cognitive performance and sensory processing.
  • Reference: Freedman, R., et al. "Alpha7-Nicotinic Receptor Gene and Sensory Gating: Neurobiological Bases of the Deficit in Schizophrenia." Biological Psychiatry, 2000.

Chromosome 4

• DCDC2 (Doublecortin Domain Containing 2): Linked to reading ability and neuronal development.
  • Reference: Deffenbacher, K.E., et al. "DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain." Proceedings of the National Academy of Sciences, 2004.

Chromosome 6

• DTNBP1 (Dystrobrevin Binding Protein 1): Implicated in cognitive ability and schizophrenia.
  • Reference: Wang, Y., et al. "The DTNBP1 (Dystrobrevin Binding Protein 1) Gene and Its Impact on General Cognitive Ability and Schizophrenia." Biological Psychiatry, 2005.
• KIBRA (WWC1): Associated with memory performance and hippocampal function.
  • Reference: Papassotiropoulos, A., et al. "Human Memory: A Genetic Approach." Advances in Neurology, 2003.

Chromosome 7

• FOXP2 (Forkhead Box P2): Involved in speech and language development.
  • Reference: Lai, C.S., et al. "A Forkhead-Domain Gene Is Mutated in a Severe Speech and Language Disorder." Nature, 2001.
• CHRM2 (Cholinergic Receptor Muscarinic 2): Linked to cognitive ability and IQ scores.
  • Reference: Dick, D.M., et al. "Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence." Behavior Genetics, 2007.

Chromosome 10

• INPP5A: Linked to cognitive ability as measured by the Mini-Mental State Examination and phonemic verbal fluency.
  • Reference: Your provided reference regarding INPP5A.

Chromosome 22

• COMT (Catechol-O-Methyltransferase): Associated with variations in IQ and executive function.
  • Reference: Barnett, J.H., et al. "Cognition in COMT Val158Met Polymorphism: Meta-Analysis of Memory and Executive Function." Biological Psychiatry, 2007.

Chromosome X

• FMR1 (Fragile X Mental Retardation 1): Causes Fragile X syndrome, associated with intellectual disability and autism.
  • Reference: Santoro, M.R., Bray, S.M., & Warren, S.T. "Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective." Annual Review of Pathology: Mechanisms of Disease, 2012.
• OPHN1 (Oligophrenin 1): Linked to intellectual disability and specific cognitive deficits.
  • Reference: Billuart, P., et al. "Oligophrenin-1 Encodes a Rho-GAP Protein Involved in X-Linked Mental Retardation." Nature, 1998.
• MECP2 (Methyl CpG Binding Protein 2): Causes Rett syndrome, a severe neurodevelopmental disorder.
  • Reference: Amir, R.E., et al. "Rett Syndrome Is Caused by Mutations in X-Linked MECP2, Encoding Methyl-CpG-Binding Protein 2." Nature Genetics, 1999.
• ARX (Aristaless Related Homeobox): Linked to intellectual disabilities and epileptic disorders.
  • Reference: Shoubridge, C., Fullston, T., Gecz, J. "ARX Spectrum Disorders: Making Inroads into the Molecular Pathology." Human Mutation, 2010.
• DMD (Dystrophin): Associated with Duchenne and Becker muscular dystrophies and varying degrees of intellectual disability.
  • Reference: Cotton, S., et al. "Cognitive and Behavioral Outcomes of Duchenne Muscular Dystrophy Boys with Mutations Disrupting the Distal Part of the DMD Gene." Journal of Clinical Neuroscience, 2005.

in Chinese?

ChatGPT

好的，这里是与智力和认知能力相关的染色体及其相关基因的列表，并附有参考文献：

染色体 1

• DISC1 (Disrupted in Schizophrenia 1)：与认知表现和大脑发育有关。
  • 参考文献：Thomson, P.A., 等. "DISC1 Genetics, Cognition and Psychopathology." Molecular Psychiatry, 2013.

染色体 2

• NRG1 (Neuregulin 1)：与认知功能和精神分裂症有关。
  • 参考文献：Stefansson, H., 等. "Neuregulin 1 and Susceptibility to Schizophrenia." American Journal of Human Genetics, 2002.

染色体 3

• CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit)：与认知表现和感觉处理有关。
  • 参考文献：Freedman, R., 等. "Alpha7-Nicotinic Receptor Gene and Sensory Gating: Neurobiological Bases of the Deficit in Schizophrenia." Biological Psychiatry, 2000.

染色体 4

• DCDC2 (Doublecortin Domain Containing 2)：与阅读能力和神经元发育有关。
  • 参考文献：Deffenbacher, K.E., 等. "DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain." Proceedings of the National Academy of Sciences, 2004.

染色体 6

• DTNBP1 (Dystrobrevin Binding Protein 1)：与认知能力和精神分裂症有关。
  • 参考文献：Wang, Y., 等. "The DTNBP1 (Dystrobrevin Binding Protein 1) Gene and Its Impact on General Cognitive Ability and Schizophrenia." Biological Psychiatry, 2005.
• KIBRA (WWC1)：与记忆表现和海马功能有关。
  • 参考文献：Papassotiropoulos, A., 等. "Human Memory: A Genetic Approach." Advances in Neurology, 2003.

染色体 7

• FOXP2 (Forkhead Box P2)：涉及言语和语言发育。
  • 参考文献：Lai, C.S., 等. "A Forkhead-Domain Gene Is Mutated in a Severe Speech and Language Disorder." Nature, 2001.
• CHRM2 (Cholinergic Receptor Muscarinic 2)：与认知能力和智商分数有关。
  • 参考文献：Dick, D.M., 等. "Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence." Behavior Genetics, 2007.

染色体 10

• INPP5A：与通过简易智力状态检查（Mini-Mental State Examination）和语音流利性测量的认知能力有关。
  • 参考文献：您提供的关于INPP5A的参考文献。

染色体 22

• COMT (Catechol-O-Methyltransferase)：与智商和执行功能的变异有关。
  • 参考文献：Barnett, J.H., 等. "Cognition in COMT Val158Met Polymorphism: Meta-Analysis of Memory and Executive Function." Biological Psychiatry, 2007.

X 染色体

• FMR1 (Fragile X Mental Retardation 1)：引起脆性X综合征，与智力障碍和自闭症有关。
  • 参考文献：Santoro, M.R., Bray, S.M., & Warren, S.T. "Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective." Annual Review of Pathology: Mechanisms of Disease, 2012.
• OPHN1 (Oligophrenin 1)：与智力障碍和特定认知缺陷有关。
  • 参考文献：Billuart, P., 等. "Oligophrenin-1 Encodes a Rho-GAP Protein Involved in X-Linked Mental Retardation." Nature, 1998.
• MECP2 (Methyl CpG Binding Protein 2)：引起雷特综合征，一种严重的神经发育障碍。
  • 参考文献：Amir, R.E., 等. "Rett Syndrome Is Caused by Mutations in X-Linked MECP2, Encoding Methyl-CpG-Binding Protein 2." Nature Genetics, 1999.
• ARX (Aristaless Related Homeobox)：与智力障碍和癫痫病有关。
  • 参考文献：Shoubridge, C., Fullston, T., Gecz, J. "ARX Spectrum Disorders: Making Inroads into the Molecular Pathology." Human Mutation, 2010.
• DMD (Dystrophin)：与杜氏和贝克肌营养不良症有关，并导致不同程度的智力障碍。
  • 参考文献：Cotton, S., 等. "Cognitive and Behavioral Outcomes of Duchenne Muscular Dystrophy Boys with Mutations Disrupting the Distal Part of the DMD Gene." Journal of Clinical Neuroscience, 2005.

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