宅妈记事
最喜小儿无赖
通常发掘老药的新功能，可以省去巨额研发及推向临床费用。 所以很多人致力于研究老药新用。 Viagra作为处方助性药物已大火数年，近来又有报道提起它可以减少老年痴呆发病率，男女使用均有效益。查了一下Google和Pubmed，似乎有些过于乐观
Dr. Desai led the study that found no evidence that Viagra and Cialis reduced the risk of Alzheimer's or related dementias, and Dr. Cheng led the study that found that Viagra was associated with a reduced risk of Alzheimer's disease. These responses have been lightly edited for length and clarity.Dec 19, 2022
Viagra could slash risk of Alzheimer’s disease by 60%: study
Viagra could cut the risk of Alzheimer’s disease by 60%, according to a new study.
Researchers from Mount Sinai Medical Center in New York found that Viagra (sildenafil), a drug most commonly used to treat erectile dysfunction, blocks an enzyme found in the brains of those who suffer from the disease.
The study looked at more than 27,000 people over 65, comparing half of the participants who had been prescribed sildenafil with half who had not. Findings showed that Viagra suppresses a protein called PDE5.
In Alzheimer’s patients, PDE5 is “significantly increased” in the part of the brain that manages memory.
“We found sildenafil was significantly associated with a 60% lower risk of developing Alzheimer’s disease,” study author Xingyue Huo told The Sun.
Original article：
