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木耳有毒！翻白草治糖尿病！----政府在澄清真相中的脚色 2010-05-01 10:29:06
信息时代的一代特征，是阿狗阿猫都能发言，奸商可以发广告，坏人可以诽谤别人，竞争者可以释放虚假信息败坏对手的信誉。政府的科研和权力机构应该在澄清真相中扮演脚色。当然，现在的状况不理想。
举例，免。
我今天只讲一个日常生活碰到的食物安全，以及不花钱治大病的偏方可靠性问题。
到网上检索：“新鲜木耳有毒”，可以得到成千上万的结果，支持这个说法。
实际上，我自己亲身试验，从枯树枝上采摘新鲜木耳，立即炒菜吃掉。从来没有中毒。好吃得很。
那么，这个错误的信息来源是谁？为什么发布如此误导人的信息？是否应该给读者造成的损失负责？要不要将他逮捕法办？
这些问题，没有答案。
类似问题得不到解决。
再举例，糖尿病人越来越多。治疗糖尿病成为网上的热点讨论。永远没有定论。随便一个说法，总是有正反两种说法。让读者无所适从。
比如，翻白草治糖尿病，请大家到网上检索，看看。说没用的人很多。那么有没有科学根据呢？正反双方都是简单的经验表达。基本上没有丝毫的科学严谨，处于街坊大妈斗嘴吵架的档次。
以我的生物化学和医学的扎实训练，决定花点时间，稍微深入钻下去，看看严格的科学研究，是否有人做，结果如何？
答案：有。
南京中医药大学研究结果用外文报道了试验结果。他们用翻白草的简单提取物在小白鼠身上做试验，发现：1）在正常健康老鼠身上没有降血糖，2）在糖尿病老鼠身上发现，可以显著降血糖。
说明：翻白草治糖尿病，不是空穴来风，是有科学根据的。这个试验结果，在外国发表的，中国人当中，知道得不多。而那些相反经验的人，要从自身找原因了。
Anti-diabetic effect of standardized extract of Potentilla discolor Bunge and identification of its active components
Jie Yang 1, Hong Chen 1, Li Zhang 1, Qiang Wang 1 *, Mao-Xiang Lai 2
1Department of Chinese Materia Medica Analysis, Pharmaceutical University, Nanjing 210009, People\'s Republic of China
2Guangxi Academy of Chinese Medicine and Pharmaceutical Science, Guangxi 530022, People\'s Republic of China
email: Qiang Wang (qwang49@163.com)
*Correspondence to Qiang Wang, Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210009, People\'s Republic of China
Keywords
Potentilla discolor • diabetes • triterpenes • flavonoids • glycogen phosphorylase
Abstract
Potentilla discolor Bunge, a Chinese folk medicine, has been used for the treatment of diabetes for many years. Unfortunately, little information is available on its bioactive components and mechanism of action. We report the anti-diabetic effect of P. discolor on normal and alloxan-induced diabetic mice, as well as the possible constituents and mechanism responsible for this activity. We found that the standardized extract of P. discolor (EPD) had little effect on the glucose levels of normal mice, while a dose-dependent hypoglycemic effect was observed in diabetic mice. Glucose tolerance test data indicated that there was a significantly higher rate of glucose disposal after EPD treatment. Phytochemical characterization indicated that the major components of EPD were triterpenes and flavonoids that could inhibit the activity of glycogen phosphorylase (GP) in vitro. Tormentic acid, asiatic acid, and potengriffioside A exhibited inhibitory effects on GP (IC50=90.6, 65.4, and 85.9 µM, respectively). The inhibition on GP may be one molecular mechanism through which EPD ameliorates hyperglycemia. These results suggest P. discolor extract may offer an alternate treatment for diabetes. Drug Dev Res, 2009. © 2009 Wiley-Liss, Inc.
Received: 14 July 2009; Accepted: 13 September 2009
信息时代的一代特征，是阿狗阿猫都能发言，奸商可以发广告，坏人可以诽谤别人，竞争者可以释放虚假信息败坏对手的信誉。政府的科研和权力机构应该在澄清真相中扮演脚色。当然，现在的状况不理想。
举例，免。
我今天只讲一个日常生活碰到的食物安全，以及不花钱治大病的偏方可靠性问题。
到网上检索：“新鲜木耳有毒”，可以得到成千上万的结果，支持这个说法。
实际上，我自己亲身试验，从枯树枝上采摘新鲜木耳，立即炒菜吃掉。从来没有中毒。好吃得很。
那么，这个错误的信息来源是谁？为什么发布如此误导人的信息？是否应该给读者造成的损失负责？要不要将他逮捕法办？
这些问题，没有答案。
类似问题得不到解决。
再举例，糖尿病人越来越多。治疗糖尿病成为网上的热点讨论。永远没有定论。随便一个说法，总是有正反两种说法。让读者无所适从。
比如，翻白草治糖尿病，请大家到网上检索，看看。说没用的人很多。那么有没有科学根据呢？正反双方都是简单的经验表达。基本上没有丝毫的科学严谨，处于街坊大妈斗嘴吵架的档次。
以我的生物化学和医学的扎实训练，决定花点时间，稍微深入钻下去，看看严格的科学研究，是否有人做，结果如何？
答案：有。
南京中医药大学研究结果用外文报道了试验结果。他们用翻白草的简单提取物在小白鼠身上做试验，发现：1）在正常健康老鼠身上没有降血糖，2）在糖尿病老鼠身上发现，可以显著降血糖。
说明：翻白草治糖尿病，不是空穴来风，是有科学根据的。这个试验结果，在外国发表的，中国人当中，知道得不多。而那些相反经验的人，要从自身找原因了。
Anti-diabetic effect of standardized extract of Potentilla discolor Bunge and identification of its active components
Jie Yang 1, Hong Chen 1, Li Zhang 1, Qiang Wang 1 *, Mao-Xiang Lai 2
1Department of Chinese Materia Medica Analysis, Pharmaceutical University, Nanjing 210009, People\'s Republic of China
2Guangxi Academy of Chinese Medicine and Pharmaceutical Science, Guangxi 530022, People\'s Republic of China
email: Qiang Wang (qwang49@163.com)
*Correspondence to Qiang Wang, Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210009, People\'s Republic of China
Keywords
Potentilla discolor • diabetes • triterpenes • flavonoids • glycogen phosphorylase
Abstract
Potentilla discolor Bunge, a Chinese folk medicine, has been used for the treatment of diabetes for many years. Unfortunately, little information is available on its bioactive components and mechanism of action. We report the anti-diabetic effect of P. discolor on normal and alloxan-induced diabetic mice, as well as the possible constituents and mechanism responsible for this activity. We found that the standardized extract of P. discolor (EPD) had little effect on the glucose levels of normal mice, while a dose-dependent hypoglycemic effect was observed in diabetic mice. Glucose tolerance test data indicated that there was a significantly higher rate of glucose disposal after EPD treatment. Phytochemical characterization indicated that the major components of EPD were triterpenes and flavonoids that could inhibit the activity of glycogen phosphorylase (GP) in vitro. Tormentic acid, asiatic acid, and potengriffioside A exhibited inhibitory effects on GP (IC50=90.6, 65.4, and 85.9 µM, respectively). The inhibition on GP may be one molecular mechanism through which EPD ameliorates hyperglycemia. These results suggest P. discolor extract may offer an alternate treatment for diabetes. Drug Dev Res, 2009. © 2009 Wiley-Liss, Inc.
Received: 14 July 2009; Accepted: 13 September 2009
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