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125 Qs we don't know
(2005-06-30 19:05:37)

ScientistsResearchingWhatWeDon'tKnow
CLINTONPARKS
UNITEDSTATES
1JULY2005
Thoughitisoften--andjustifiably--maligned,itisignorance--andrecognizingwhereitexists--thatdrivesscientiststodogroundbreakingscience.Forearlycareerscientists,ignorance--andknowingwhatareasweareignorantof--alsoprovidescompellingprofessionalopportunities.ThatiswhywehavechosentosupplementSciencemagazine's125thAnni...[阅读全文]
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Sensory Systems: Taste Percept
(2005-06-28 18:03:47)

TeachingResources
Home>Resources>TeachingResources>Margolskee,pp.tr20
Sci.STKE,Vol.2005,Issue290,pp.tr20,28June2005
[DOI:10.1126/stke.2902005tr20]SensorySystems:TastePerceptionRobertF.Margolskee*DepartmentofPharmacologyandBiologicalChemistry,MountSinaiSchoolofMedicine,NewYork,NY10029,USA.
Abstract:ThisTeachingResourceprovideslecturenotesandslidesforaclasscoveringthehumanta...[阅读全文]
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nanotech: cell motility assay
(2005-06-28 17:12:03)

Protocols
Home>Literature>Protocols>Guetal.,pp.pl5http://stke.sciencemag.org/cgi/reprint/sigtrans;2005/290/pl5.pdf
Sci.STKE,Vol.2005,Issue290,pp.pl5,28June2005
[DOI:10.1126/stke.2902005pl5]QuantumDot-BasedCellMotilityAssayWeiweiGu1,TeresaPellegrino2,WolfgangJ.Parak2,RosanneBoudreau1,MarkA.LeGros3,DanieleGerion2,A.PaulAlivisatos2,andCarolynA.Larabell1,3*1DepartmentofAnatomy,Uni...[阅读全文]
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Real-time RNA in a single cell
(2005-06-28 17:03:31)
http://www.pnas.org/cgi/reprint/102/26/9160CharacterizingthedynamicsofspecificRNAlevelsrequiresrealtimeRNAprofilinginasinglecell.Weshowthatthecombinationofasyntheticmodulargeneticsystemwithfluorescencecorrelationspectroscopyallowsustodirectlymeasureinrealtimetheactivityofanyspecificpromoterinprokaryotes.Usingasimpleinduciblegeneexpressionsystem,wefoundthatinducedRNAlevelswithinasinglebacteriumofEs...[阅读全文]
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community proteomics of Biofil
(2005-06-24 11:01:09)

OriginallypublishedinScienceExpresson5May2005
Science,Vol308,Issue5730,1915-1920,24June2005
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Ram,R.J.||Banfield,J.F.Requestper...[阅读全文]
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Junk DNA makes sense
(2005-06-15 08:53:42)

NewsoftheWeekGENETICS:
InVoles,aLittleExtraDNAMakesforFaithfulMatesElizabethPennisiPrairievolesarerenownedforbeingfaithfulmates,butsomeindividualsaremorefaithfulthanothers.Thedifferencemaylieintheirso-calledjunkDNA.Onpage1630,ElizabethHammockandLawrenceYoungofEmoryUniversityinAtlanta,Georgia,reportthatfidelityandothersocialbehaviorsinmaleprairievolesseemtodependonthelengthofaparticulargenetics...[阅读全文]
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Old techniques in new field!
(2005-06-15 08:28:32)
Thehumangutcontainsseveralhundredspeciesofmicrobesandroughlyhalfthetotalnumberofcellsinourbodies.However,weknowalmostnothingaboutthesecohabitantsortheircontributiontohumanhealthanddisease.Eckburgetal.(p.1635,publishedonline14April2005)describethemicrobialdiversityatvarioussitesinthecolonsofthreehealthypeopleby16SribosomalRNA-basedanalysisandofferacomprehensive,detailedmolecularsurveyofthemicrobiot...[阅读全文]
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Metagenomics->Metaproteomics?
(2005-06-03 12:09:21)

NatureReviewsMicrobiology3,447(2005);doi:10.1038/nrmicro1186Metagenomics
INTHISISSUENatureReviewsMicrobiologyisdelightedtopresentaspecialissuedevotedtotheemergingfieldofmetagenomics—theculture-independentgenomicanalysisofanassemblageofmicroorganisms.Untilnow,thefocusofmicrobialgenomicshasbeenonthestudyofindividualmicrobialstrains.Outsidethelaboratory,however,almostallmicroorganismsexistincomp...[阅读全文]
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How much or what you eat?
(2005-06-01 15:04:21)
Nature435,548(2June2005)|doi:10.1038/nature03861YeastfeedsdebateonprolonginglifeCarinaDennisTopofpageAbstractFruitfliesgrowolderwhencertainfoodsarecut.'Eatinglesshelpsyoulivelonger'hasfordecadesbeenthemessagefromresearchersofageing.Soexpertsarenotsurewhattomakeofastudyinfliesthatsuggestsitcouldbewhatyoueat,nothowmuchyoueat,thatreallycounts.Theideathatrestrictingcaloriesprolongslifespanwasfirstrepo...[阅读全文]
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Structural Genomics
(2005-06-01 14:58:14)
Thefieldofstructuralgenomicsaimstorevealtheshapesofproteinsbyusingtheinformationobtainedfromgenome-sequencingprojectsinautomated,high-throughputschemes.ThesewouldsynthesizethousandsofproteinsinvitrosothattheycouldbeexaminedbyX-raycrystallographyandnuclearmagneticresonancetechniques,whichareusedtoimagemoleculesinthreedimensions.[阅读全文]
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