华陀再世
一个中国医学生(CMG)在美国的生活。。。
正文
马萨诸塞州，波士顿讯—来自两项前瞻性的队列研究的数据显示，ABO血型是发生冠状动脉性心脏病的危险因素。A、B或AB型血的人较O型血的人患冠状动脉性心脏病的风险要高5%至23%，经多变量调整其他危险因素或饮食因素后，这种相关性仍存在。
这项由Meian He博士（Harvard School of Public Health, Boston, MA）进行的分析包括了NHS研究中的62073名女性和HPFS研究中的27428名男性。结果发表在2012年9月的《动脉硬化、血栓和血管生物学》杂志上。
在NHS和HPFS研究中，冠心病的发病率在O、A、B和AB型的妇女分别为125、128、142和161人每100000人每年；O、A、B和AB型的男性分别为373、382、387和524人每100000人每年。在调整年龄后的模型中，与O型血的人相比，A、B、AB型血的人患冠心病的风险分别上升5%， 11%，和23%。在多变量调整后的模型中，这一血型与患病风险的伴随关系没有显著改变。ABO血型与患冠心病之间经年龄调整后的风险比（95%可信区间）研究者同时进行分析，检验非O型血的人患冠心病的风险。与O型血的人相比，A、B和AB型血的人患冠心病的风险升高9%，经调整其他危险因素后，此风险有所改变。
类似的，将NHS、HPFS和其他四项前瞻性研究结合起来进行分析，共包括了114648名对象，发现非O型血的人较O型血的人，患冠心病的风险增高6%。据研究者说，总体上，超过6%的冠心病发病可归咎于A、B或AB血型。
关于风险上升的可能机制， He等人认为，那些非O型血的人，血浆中vWF水平较O型血的人要高将近25%。而vWF水平的升高已被证实是冠心病的危险因素。“vWF在凝血和血栓形成、介导血小板粘附于血管壁的过程中，起重要作用，尤其是在高切应力的条件下。”He和他的团队解释说：“同纤维蛋白原一起，vWF还参与血小板聚集，并在粥样硬化形成过程中扮演重要角色。”另外A型血的人，其总胆固醇和LDL的水平较高。
August 14, 2012 (Boston, Massachusetts) — Data from two prospective cohort studies have identified the ABO blood group as a risk factor for the development of coronary heart disease. Individuals with blood groups A, B, or AB were 5% to 23% more likely to develop coronary heart disease compared with subjects with O blood type, and the associations were not altered by multivariate adjustment of other risk or dietary factors.
The analysis, led by Dr Meian He (Harvard School of Public Health, Boston, MA), included 62 073 women from the Nurses' Health Study (NHS) and 27 428 men from the Health Professionals Follow-up Study (HPFS) and is published in the September 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology.
In the NHS and HPFS, the incident rates of coronary heart disease per 100 000 person-years were 125, 128, 142, and 161 for women with type O, A, B, and AB, respectively, and 373, 382, 387, and 524 for men with type O, A, B, and AB, respectively. Compared with individuals with O blood type, individuals with blood group A, B, or AB had a respective 5%, 11%, and 23% increased risk of developing coronary heart disease in an age-adjusted model. These associations were not significantly altered in the multivariable-adjusted risk model. The researchers also performed an analysis examining the risk of coronary heart disease in patients with non-O blood type. Compared with individuals with O blood type, those with A, B, and AB had a 9% increased risk of developing coronary heart disease, and this risk was unaltered after adjustment for other risk factors.
Similarly, a combined analysis of NHS and HPFS with four other prospective studies, an analysis that included 114 648 subjects, found there was a 6% increased risk of coronary heart disease for those with non-O blood type compared with individuals with O blood.In total, just over 6% of the coronary heart disease cases were attributable to the A, B, or AB blood types, according to the researchers.In terms of possible underlying mechanisms for the increased risk,
He et al note that in non-O individuals, plasma levels of factor VIII-von Willebrand factor (vWF) are approximately 25% higher than in individuals with type O blood type. Elevated levels of factor VIII-vWF have been previously identified as a risk factor for coronary heart disease."The vWF has an important role in hemostasis and thrombosis by mediating platelet adhesion to the vascular wall, especially under high shear stress conditions," explain He and colleagues. "Along with fibrinogen, vWF also participates in platelet aggregation and plays a role in the development of atherosclerosis." In addition, the A blood group has been shown to have higher levels of total and LDL cholesterol.
这项由Meian He博士（Harvard School of Public Health, Boston, MA）进行的分析包括了NHS研究中的62073名女性和HPFS研究中的27428名男性。结果发表在2012年9月的《动脉硬化、血栓和血管生物学》杂志上。
在NHS和HPFS研究中，冠心病的发病率在O、A、B和AB型的妇女分别为125、128、142和161人每100000人每年；O、A、B和AB型的男性分别为373、382、387和524人每100000人每年。在调整年龄后的模型中，与O型血的人相比，A、B、AB型血的人患冠心病的风险分别上升5%， 11%，和23%。在多变量调整后的模型中，这一血型与患病风险的伴随关系没有显著改变。ABO血型与患冠心病之间经年龄调整后的风险比（95%可信区间）研究者同时进行分析，检验非O型血的人患冠心病的风险。与O型血的人相比，A、B和AB型血的人患冠心病的风险升高9%，经调整其他危险因素后，此风险有所改变。
类似的，将NHS、HPFS和其他四项前瞻性研究结合起来进行分析，共包括了114648名对象，发现非O型血的人较O型血的人，患冠心病的风险增高6%。据研究者说，总体上，超过6%的冠心病发病可归咎于A、B或AB血型。
关于风险上升的可能机制， He等人认为，那些非O型血的人，血浆中vWF水平较O型血的人要高将近25%。而vWF水平的升高已被证实是冠心病的危险因素。“vWF在凝血和血栓形成、介导血小板粘附于血管壁的过程中，起重要作用，尤其是在高切应力的条件下。”He和他的团队解释说：“同纤维蛋白原一起，vWF还参与血小板聚集，并在粥样硬化形成过程中扮演重要角色。”另外A型血的人，其总胆固醇和LDL的水平较高。
August 14, 2012 (Boston, Massachusetts) — Data from two prospective cohort studies have identified the ABO blood group as a risk factor for the development of coronary heart disease. Individuals with blood groups A, B, or AB were 5% to 23% more likely to develop coronary heart disease compared with subjects with O blood type, and the associations were not altered by multivariate adjustment of other risk or dietary factors.
The analysis, led by Dr Meian He (Harvard School of Public Health, Boston, MA), included 62 073 women from the Nurses' Health Study (NHS) and 27 428 men from the Health Professionals Follow-up Study (HPFS) and is published in the September 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology.
In the NHS and HPFS, the incident rates of coronary heart disease per 100 000 person-years were 125, 128, 142, and 161 for women with type O, A, B, and AB, respectively, and 373, 382, 387, and 524 for men with type O, A, B, and AB, respectively. Compared with individuals with O blood type, individuals with blood group A, B, or AB had a respective 5%, 11%, and 23% increased risk of developing coronary heart disease in an age-adjusted model. These associations were not significantly altered in the multivariable-adjusted risk model. The researchers also performed an analysis examining the risk of coronary heart disease in patients with non-O blood type. Compared with individuals with O blood type, those with A, B, and AB had a 9% increased risk of developing coronary heart disease, and this risk was unaltered after adjustment for other risk factors.
Similarly, a combined analysis of NHS and HPFS with four other prospective studies, an analysis that included 114 648 subjects, found there was a 6% increased risk of coronary heart disease for those with non-O blood type compared with individuals with O blood.In total, just over 6% of the coronary heart disease cases were attributable to the A, B, or AB blood types, according to the researchers.In terms of possible underlying mechanisms for the increased risk,
He et al note that in non-O individuals, plasma levels of factor VIII-von Willebrand factor (vWF) are approximately 25% higher than in individuals with type O blood type. Elevated levels of factor VIII-vWF have been previously identified as a risk factor for coronary heart disease."The vWF has an important role in hemostasis and thrombosis by mediating platelet adhesion to the vascular wall, especially under high shear stress conditions," explain He and colleagues. "Along with fibrinogen, vWF also participates in platelet aggregation and plays a role in the development of atherosclerosis." In addition, the A blood group has been shown to have higher levels of total and LDL cholesterol.
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