洲河的博客

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刚刚发现,不同公司的疫苗都增加了两个脯氨酸,让人倒吸一口冷气

(2021-06-11 09:14:14) 下一个

还记得MIT的Dr. Seneff专门提到增加这两个Proline在spike蛋白beta片层形成中的作用,"inviting for prion protein formation",今天查了一下,这么可怕的事实居然是公开的,而且大大地自吹自擂过了。

“Other companies, including Johnson & Johnson, Novavax, and Pfizer, are hoping the 2P mutation works for their COVID-19 vaccines too.”

“Days before (2020年1月10号), his lab at the US National Institute of Allergy and Infectious Diseases (NIAID) had partnered with the biotech company Moderna to design an experimental vaccine for the virus, which causes the disease COVID-19. All they’d needed to start was that sequence.”

看看他们bragging的,这两个proline在MERS的时候就设计好了。

"As Norbert Pardi, an mRNA vaccine scientist at the University of Pennsylvania, puts it, we’re “very lucky, actually,” that scientists worked out the 2P mutation for a MERS vaccine before the COVID-19 pandemic. “It wouldn’t be possible to go so fast with the Moderna vaccine otherwise.”

Fortuitously, Graham and a former postdoc, Jason McLellan, devised a solution to this problem before the pandemic. Through a bit of structural biology and persistent protein engineering, McLellan discovered that adding two prolines—the most rigid of the 20 amino acids—to a key joint of a vaccine’s spike protein could stabilize the structure’s prefusion shape. This 2P mutation worked in preclinical studies of Graham and Moderna’s MERS vaccine, so they applied it to Moderna’s COVID-19 vaccine.”

 

https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behind-COVID-19/98/i38? 

 

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