PricessoarforcancerdrugsUpdated7/11/20069:04AMETE-mail|Save|Print|Reprints&Permissions|EnlargeGenentechhandoutAvastin,anewerdrugusedtotreatcolorectalcancer,sellsforabout$50,000ayear.Thatpricecouldjumpto$100,000ifAvastinisapprovedtotreatbreastandlungcancers,whichrequirehigherdoses.LONGERLIFE,HIGHERCOSTEffectofdrugsonpatientswhohaveadvancedcolorectalcancer:Fordrugsavailablein1996
Totalcost:$...[
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SalesofApprovedKinaseDrugs#DrugCompanyApprovalDate$millions(2005)$millions(2006)‘05–‘06growth1Gleevec*Novartis2001$2,200$2,60018%2AvastinGenentech2004$1,133$1,74654%3HerceptinGenentech1998$764$1,23462%4ErbituxImClone/BMS2004$698$1,10058%5Tarceva*OSI/DNA2004$311$650109%6LucentisGenentech2006-$3807Iressa*AstraZ2003$273$237-13%8Sutent*Pfizer2006-$2199Nexavar*Onyx/Bayer2006-$16510MacugenOSI/DNA2004...[
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Newsoftheday:Inpts[patients]withPRC,XL-880demonstratedantitumoractivityNameTargetCompanyPhaseAZD-2171Vegfc-KitPdgfr-βAstraZenecaph2AZD-2171Vegfc-KitPdgfr-βAstraZenecaph2PD-325901MekPfizerph2XL-647ErbB1,2Vegfr-2Exelixisph2XL-880c-MetVegfExelixisph2ARQ-197c-MetArquleph1BAY-579352Vegfr-2,3c-KitPdgfr-βBayerph1BAY-734506c-KitRetPdgfrRafBayerph1BIBW-2992ErbB(irrev)BIph1PD-325901MekPfizerph1PF-299804E...[
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Selectivevs.NonselectiveOct25th,2007bykinaseproThereareahandfulofwaystovisualizeselectivityamongkinaseinhibitorsafteryou’vehadthemProfiled.ThegoldstandardhasbecometheAmbitpanel:(fromtheNatureBiotechpaper)Asimplechartwillgetthejobdone:(INNO-406/NS-187,fromBlood05,3948)oraheatmaplikeAmphoras’:Ifyoupreferareductionistapproachyou’vealwaysbeenabletotakeitdowntoasinglenumberwithfoldshiftfromitsneares...[
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Pfizer’sFailureinGoodCholesterolDoesn’tDoomRivalsPostedbyNickTimiraosResearchersshedalittlemorelightonwhatwentsobadlywrongwithPfizer’storcetrapib(pictured)duringapresentationattheAmericanHeartAssociation’sconfabinOrlando.BesidesboostingHDL,orgood,cholesterollevels,torcetrapibsharplyincreasedrisksofdeathduringtrials.Pfizerspikedthemammothdrug-developmentprogramlastDecemberaftertorcetrapibspurre...[
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CHICAGO–Bloodclottingisfourtofivetimesmorelikelytooccurinpatientswhohavedrug-coatedheartdevicesknownasstents,comparedwiththeolderbare-metalvariety,accordingtoalargedataanalysisbytheClevelandClinicreleasedWednesday.TheanalysiscomesoneweekbeforeaU.S.FoodandDrugAdministrationpanelofexpertsmeetstodiscusslatestentthrombosis,orpotentiallyfatalbloodclotting,longafterthedevices,alsoknownasdrug-elutingste...[
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NEWYORK,Oct23(Reuters)-AsmallstudypresentedonMondaysuggestsEliLillyandCo.'s(LLY.N:Quote,Profile,Research)experimentalbloodclotpreventer,prasugrel,worksfasterandcouldbemoreeffectivethanthecommonlyuseddoubledosageofPlavix,theblockbusteranti-clotmedicine.Thirty-threehealthyaspirin-freesubjectscompletedthePhaseItrial.Althoughnottheheart-diseasepopulationforwhomsuchadrugwouldeventuallybeused,thestudyma...[
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心血管病的发病率和死亡率都居美国首位，因此美国心脏学会(A-HA)为预防本病于2006年7月推出新的饮食指南，较2000年版本有不少改进，操作更切合实际，很值得我们参考。
新指南认为饮食仅仅是健康生活方式的一部分，饮食和活动是不可分的，两者都联系到整个生活方式。
新指南的目标是促使：①食用完全健康的饮食；②达到健康体重(体质指数BMI18.5～24.9)(我国应稍低40[
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CHICAGO,Sept8(Reuters)-Oneofthenation'sleadingcardiologistsiscallingforasweepingstudythatevaluatestherisksofpotentiallyfatalbloodclotsrelatedtowidelyusedheartdevicesthattreatblockedheartarteries.Nearly6millionheartpatientsworldwidehavereceivedaso-calleddrug-elutingstent,atinywiremeshtubethatiscoveredwithadrugthatreducesscarformationandkeepsvesselsfromreclosing.Buttherehasbeenagrowingbodyofevidence...[
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Thebodyneedsomega-3’sbutcan’tproducethemonitsown.
Omega-3fattyacids,atypeofpolyunsaturatedfattyacids,mustcomefromthediet.Thebestknownsourcesarefish,shellfish,fishoilsandorganmeats(mmm…organmeats).Thenutrientsnaturallyoccurringinleafygreens,nutsandflaxseedalsoprovidethefattyacidsweneed.
Thebodyconvertsthesefoodsintohormone-likebiochemicalsitusesforcrucialfunctionsincludingcellgrowth,brai...[
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