高危人群胰腺癌筛查

Screening protocol parameters based on risk factor

Risk Factor	Increased Risk	Mean age at PC dx	Age at which screening should begin	Total years of screening
Peutz-Jehgers Syndrome	132x	40.8	30	20
Hereditary Pancreatitis	87x	54.2	45	20
p16-Leiden mutation	48x	59	50	20
Familial PC (>2 first-degree relatives with PC)	32x	NA	50, or 10 years before youngest PC dx in blood relative	20
New-onset diabetes > age 50, with hx weight loss or smoking	8x	71a	Time of diabetes dx	3

aSEER median age of PC diagnosis in general population

PC pancreatic cancer, hx history, dx diagnosis