为什么MB越来越被认可？

Methylene Blue (MB), also known as methylthioninium chloride, in Chinese is translated as 亚甲蓝 (Yà jiǎ lán) or 甲基噻氯化铵。

 

### What is Methylene Blue?

Methylene Blue (MB), also known as methylthioninium chloride, is a synthetic compound originally developed in 1876 as a textile dye. It appears as a dark green powder that turns vibrant blue when dissolved in water. Over time, its unique chemical properties, including its ability to act as an electron carrier and antioxidant, led to its use in medical and scientific applications. It is FDA-approved for treating methemoglobinemia （高铁血红蛋白血症.）, a rare blood disorder that impairs oxygen delivery in red blood cells, but it has also been used off-label for various medical and wellness purposes.[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)[]

(https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

 

### Benefits of Methylene Blue

Methylene Blue has a range of established and emerging benefits, supported by varying levels of scientific evidence. Below are its key benefits, based on research and clinical use:

1. **FDA-Approved Use: Treatment of Methemoglobinemia**
   - MB is a first-line treatment for methemoglobinemia, rapidly restoring hemoglobin’s oxygen-carrying capacity. It is typically administered intravenously under medical supervision.[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)[]

(https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)

 

2. **Cognitive and Neurological Support**
   - **Memory and Focus**: Preliminary studies, including a small human trial (26 adults), showed low-dose MB improved memory retrieval by ~7% and increased brain activity in areas linked to memory and attention. Animal studies suggest it enhances spatial memory and brain metabolism.[](https://x.com/bryan_johnson/status/1954969679413616967)[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)

   - **Neuroprotection**: MB may protect neurons from oxidative stress and inflammation, potentially slowing neurodegenerative diseases like Alzheimer’s and Parkinson’s. In animal models, it reduced amyloid-β and tau protein aggregation, key markers of Alzheimer’s.[](https://x.com/bryan_johnson/status/1954969677664489491)[]

(https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

   - **Mood Enhancement**: As a monoamine oxidase inhibitor (MAOI), MB has shown antidepressant effects in some studies, particularly for treatment-resistant depression. However, it carries risks of serotonin syndrome when combined with certain antidepressants (e.g., SSRIs).[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)

 

3. **Anti-Aging and Mitochondrial Health**
   - MB supports mitochondrial function by enhancing ATP production and reducing oxidative stress, which may slow cellular aging. It’s being explored in anti-aging skincare and wellness routines for its potential to improve skin elasticity and reduce wrinkles, though human evidence is limited.[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)[]

(https://publichealthpolicyjournal.com/the-science-and-benefits-of-methylene-blue/)

   - Posts on X and wellness blogs highlight its use in biohacking for longevity, citing its role in boosting cellular energy.

4. **Antimicrobial and Antiviral Properties**

   - MB has broad-spectrum antimicrobial effects, historically used to treat infections like gonorrhea （ 淋病.） and urinary tract infections. It’s being studied for its potential against viruses like SARS-CoV-2, Zika, and Ebola, particularly in photodynamic therapy, though it’s not FDA-approved for these uses.[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

   - In veterinary medicine and aquariums, MB treats fungal infections and parasites.[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

 

5. **Medical and Diagnostic Uses**
   - **Surgical Applications**: MB is used as a dye to map lymph nodes during cancer surgeries or to highlight abnormalities in procedures like colonoscopies.[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

   - **Other Off-Label Uses**: MB treats conditions like vasodilatory shock （血管扩张性休克）, cyanide poisoning（氰化物中毒）, oral mucositis （口腔黏膜炎）, and ifosfamide-induced encephalopathy （异环磷酰胺诱发的脑病）. It’s also used in chromoendoscopy （染色内镜检查.）to detect digestive tract abnormalities.[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)

 

### Why Is Methylene Blue Popular Now?

Methylene Blue’s recent surge in popularity, particularly in 2025, stems from several factors:

1. **Celebrity and Influencer Endorsements**
   - High-profile figures like Joe Rogan, Robert F. Kennedy Jr., Selena Gomez, and Millie Bobby Brown have discussed MB’s potential cognitive and wellness benefits, sparking public interest. For example, RFK Jr.’s in-flight video discussing MB in early 2025 went viral, and Joe Rogan praised it on his podcast for enhancing mitochondrial function.[](https://stemcellstulum.org/regenerative-medicine/methylene-blue/)

   - These endorsements, amplified by social media platforms like TikTok, have driven MB’s visibility among wellness enthusiasts and biohackers.[](https://www.wellandgood.com/health/methylene-blue-tiktok-trend)

 

2. **Biohacking and Wellness Trends**
   - MB’s ability to enhance mitochondrial function and energy production has made it a favorite in the biohacking community, who seek to optimize health and longevity. Posts on X highlight its use for “brain fuel” and cellular energy.[](https://galaxy.ai/youtube-summarizer/understanding-methylene-blue-the-science-behind-its-popularity-and-benefits-3ASnRAULLw4)

   - Its affordability compared to other supplements and accessibility in pharmaceutical-grade forms (e.g., from brands like Earth Harmony) has fueled its adoption.[](https://www.luxurylifestylemag.co.uk/health-wellbeing/from-history-to-modern-day-popularity-the-ongoing-interest-in-methylene-blue/)

 

3. **Social Media Hype**
   - TikTok trends show users consuming MB for alleged brain-boosting and anti-aging benefits, often displaying blue-tinted tongues or drinks. This visual appeal and the promise of cognitive enhancement have made it a viral sensation, though experts warn against unregulated use.[](https://www.wellandgood.com/health/methylene-blue-tiktok-trend)[](https://www.modern-endocrine.com/methylene-blue-hype-or-healing-what-you-need-to-know-about-this-mitochondrial-therapy/)

4. **Emerging Research**
   - Ongoing studies into MB’s potential for neurodegenerative diseases, cognitive enhancement, and antiviral applications have kept it in the scientific spotlight. While human trials are limited, preliminary animal studies and small-scale human data (e.g., MRI studies showing increased brain connectivity) have fueled optimism.[](https://x.com/bryan_johnson/status/1954969679413616967)[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)

5. **Market Growth and Accessibility**
   - The supplement industry has seen a boom in MB products, with companies like Earth Harmony emphasizing high-purity formulations. However, the lack of clear regulatory guidelines has led to concerns about product quality, as some formulations may contain impurities.[](https://www.luxurylifestylemag.co.uk/health-wellbeing/from-history-to-modern-day-popularity-the-ongoing-interest-in-methylene-blue/)[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)

### Risks and Considerations
- **Side Effects**: MB can cause blue urine (harmless), nausea, dizziness, or, at high doses, serotonin syndrome, especially with antidepressants. It’s contraindicated for those with G6PD deficiency or on certain medications.[](https://www.drugs.com/medical-answers/what-benefits-methylene-blue-3579794/)[](https://academicchemlab.com/blogs/news/methylene-blue-the-surprising-benefits-risks-and-uses-of-this-blue-wonder)

- **Quality Concerns**: Industrial-grade MB (e.g., for aquariums) is unsafe for human use. Only pharmaceutical-grade MB should be used, under medical supervision.[](https://www.health.harvard.edu/diseases-and-conditions/what-to-know-about-methylene-blue)[](https://www.wellandgood.com/health/methylene-blue-tiktok-trend)

- **Limited Evidence**: Many benefits (e.g., cognitive enhancement, anti-aging) are based on preliminary or animal studies, requiring more robust human trials.[](https://www.wellandgood.com/health/methylene-blue-tiktok-trend)[](https://brewminate.com/blue-promises-murky-truths-the-methylene-blue-hype-and-its-hidden-risks/)

 

### Conclusion
Methylene Blue is a versatile compound with established medical uses and promising, though not fully proven, benefits in cognitive enhancement, neuroprotection, and anti-aging. Its current popularity in 2025 is driven by celebrity endorsements, social media trends, and interest in biohacking, but caution is advised due to risks and regulatory gaps. Always consult a healthcare professional before using MB, especially for off-label purposes, and ensure you use pharmaceutical-grade products from reputable sources.

****************

Top 5 brand in NA:

Based on recent reviews, consumer feedback, and expert analyses from sources like consumer reports, supplement guides, and wellness websites, the following are the top five Methylene Blue (MB) brands in North America for 2025, focusing on pharmaceutical-grade quality, purity, effectiveness, and consumer trust. These rankings are derived from sources such as consumerreportsusa.com, bestfornutrition.com, and others, emphasizing USP-grade products with third-party testing.[](https://consumerreportsusa.com/Methylene-Blue)[](https://bestfornutrition.com/best-methylene-blue-supplements/)

### Top 5 Methylene Blue Brands in North America
1. **Earth Harmony Naturals Methylene Blue** ( Unfortunately, from its website, it seems cannot be sent to Canada, currently, not sure why)
   - **Why It Ranks #1**:
     - **Purity and Quality**: Offers 99.99% USP-grade MB, free from formaldehyde and other contaminants, third-party tested for heavy metals.
     - **Formulation**: 1% solution in a 2 oz UV-protected glass bottle with a dropper for precise dosing. Includes Nano Liquid Gold for enhanced absorption and photodynamic activity.
     - **Benefits**: Highly praised for boosting mental clarity, energy, and mitochondrial function. Users report improved focus, sleep quality, and emotional well-being.
     - **Consumer Feedback**: Rated highly on Amazon (4.4/5 from 967+ reviews) for cognitive support and ease of use. Popular among biohackers.
   - **Pros**:
     - Pharmaceutical-grade with rigorous testing.
     - Affordable pricing (~$28.00 for 2 oz).
     - Convenient dropper for daily use.
   - **Cons**:
     - May cause temporary blue staining of teeth or urine.
     - Slightly bitter taste reported by some.
   - **Availability**: Available on Amazon and Earth Harmony’s official site.[](https://supplementinstitute.org/vitamin-supplements/best-methylene-blue)[](https://www.bestproductsreviews.com/methylene-blue-pharmaceutical-grade)

 

2. **AccuaBoost Premium USP Grade Methylene Blue**
   - **Why It Ranks #2**:
     - **Advanced Technology**: Features proprietary electron transport chain optimization, maintaining bioactive MB levels 4x longer than competitors, with 99.9% USP-grade purity.
     - **Performance**: Lab tests showed superior mitochondrial activation and cognitive enhancement. A 28-day study with 237 participants reported significant energy and mental clarity improvements.
     - **Value**: Priced at $34.97 (down from $42.99), with free 2-4 day shipping and a 30-day satisfaction guarantee. Over 10,000 5-star Google reviews.
   - **Pros**:
     - Exceptional bioavailability and stability.
     - Heavy metal testing to parts per billion (ppb).
     - Strong consumer trust and value for money.
   - **Cons**:
     - Limited availability due to high demand (often out of stock).
     - Only sold through the official website, not retail stores.
   - **Availability**: Direct-to-consumer via AccuaBoost’s website.[](https://consumerreportsusa.com/Methylene-Blue)

3. **aSquared Nutrition Methylene Blue (Capsules and Drops)**
   - **Why It Ranks #3**:
     - **Versatility**: Offers both capsule (12mg, 120 capsules) and liquid (1% solution, 2 fl oz) forms, catering to different preferences. Capsules include vitamin C and cacao powder for enhanced absorption.
     - **Quality**: USP-grade, third-party tested, non-GMO, and GMP-certified. Capsules are light-protective to maintain stability.
     - **Benefits**: Highly rated (4.5/5 from 58+ Amazon reviews) for cognitive support, mental clarity, and mitochondrial energy. Users note improvements in memory and focus within 1-2 weeks.
   - **Pros**:
     - Capsule form avoids staining issues of liquids.
     - Synergistic nootropic blend (vitamin C, cacao, ALA).
     - Affordable (~$24.95 for capsules, $4.99/fl oz for drops).
   - **Cons**:
     - Capsules may have a higher per-serving cost (~$0.42/count).
     - Some users report underfilled bottles.
   - **Availability**: Widely available on Amazon and aSquared Nutrition’s site.[](https://bestfornutrition.com/best-methylene-blue-supplements/)

4. **Compass Laboratory Methylene Blue**
   - **Why It Ranks #4**:
     - **Quality**: Pharmaceutical-grade, USP-grade 1% solution, third-party tested, free from formaldehyde and alcohol. Made in the USA in a GMP-certified facility.
     - **Benefits**: Praised for improving mental clarity, focus, and energy. Users report reduced brain fog and better mood, with a 9.5/10 rating in some reviews.
     - **Packaging**: 50ml glass dropper bottle ensures precise dosing and stability.
   - **Pros**:
     - High purity and reliable testing.
     - Easy-to-use dropper for flexible dosing.
     - Strong customer feedback for cognitive benefits.
   - **Cons**:
     - Higher price point (~$136 for 50ml in some listings).
     - Slightly bitter taste noted by some users.
   - **Availability**: Available on Amazon and Compass Laboratory’s official site.[](https://rebatekey.com/guides/health/best-methylene-blue-supplement/)[](https://www.bestchoice.com/comparison/methylene-blue)

5. **Artnaturals Methylene Blue 1% Solution**
   - **Why It Ranks #5**:
     - **Unique Formulation**: Combines USP-grade 1% MB with balanced electrolytes for enhanced absorption and cellular hydration. Third-party tested for purity.
     - **Benefits**: Noted for cognitive support, mitochondrial function, and hydration. High customer satisfaction (4.4/5 from 967+ Amazon reviews) for mental clarity and energy without jitters.
     - **Packaging**: 2 fl oz UV-protected glass bottle with a dropper, ideal for daily use.
   - **Pros**:
     - Electrolyte blend enhances brain health benefits.
     - Affordable (~$29.97 for 2 fl oz).
     - No formaldehyde or allergens.
   - **Cons**:
     - Electrolyte blend not fully disclosed on the label.
     - May stain surfaces or mouth if mishandled.
   - **Availability**: Available on Amazon and Artnaturals’ official site.[](https://bestfornutrition.com/best-methylene-blue-supplements/)[](https://www.bestproductsreviews.com/methyleneblue)

### Why These Brands?
- **Purity and Safety**: All brands offer pharmaceutical-grade MB (≥99.7% purity), third-party tested to ensure no contaminants like heavy metals or formaldehyde, critical for safe consumption.
- **Consumer Trust**: High ratings on platforms like Amazon and Google, with consistent positive feedback for cognitive and energy benefits, align with the growing biohacking trend in North America.
- **Accessibility**: Available through trusted retailers like Amazon or direct brand websites, ensuring reliability and consumer confidence.
- **Market Relevance**: These brands are frequently cited in 2025 supplement rankings for their effectiveness, value, and alignment with wellness trends fueled by social media and celebrity endorsements (e.g., Joe Rogan, RFK Jr.).

### Notes and Considerations
- **Regulation**: MB supplements are not FDA-approved for cognitive or anti-aging uses, so pharmaceutical-grade products from reputable brands are essential. Consult a healthcare provider, especially if taking medications like SSRIs, due to risks like serotonin syndrome.
- **North American Focus**: These brands dominate in the U.S. and Canada, where MB’s popularity has surged due to biohacking and social media trends on platforms like TikTok and X.
- **Other Brands**: Brands like NBL (Norwegian BioLabs) and Meraki Medicinals are also notable but were edged out due to availability issues (e.g., frequent stock shortages for NBL) or less consistent performance data (e.g., Meraki’s vague concentration info).[](https://avasreview.com/top-5-methylene-blue-2024/)[](https://metapress.com/finding-the-right-methylene-blue-supplement-a-science-based-guide/)

 

 

*********************

Determining the definitive "top 3 brands" of Methylene Blue (MB) globally is challenging due to limited comprehensive data on worldwide market share, sales figures, or consumer preferences specifically for MB supplements in 2025. However, based on recent reviews, consumer feedback, and expert analyses from sources like consumer reports, supplement guides, and wellness websites, certain brands consistently stand out for their quality, purity, and reputation in the pharmaceutical-grade MB market. Below are the top three Methylene Blue brands frequently highlighted for their high-quality formulations, based on available information:

### Top 3 Methylene Blue Brands
1. **Earth Harmony Naturals Methylene Blue**
   - **Why It Stands Out**:
     - **Purity and Quality**: Offers pharmaceutical-grade, USP-grade MB with 99.99% purity, free from harmful additives like formaldehyde. Third-party tested for heavy metals and impurities.
     - **Ease of Use**: Comes in a 2 oz glass bottle with a dropper for precise dosing, ensuring stability and convenience.
     - **Consumer Feedback**: Highly rated for boosting mental clarity, energy, and mitochondrial function. Users report noticeable cognitive improvements and better sleep.[](https://supplementinstitute.org/vitamin-supplements/best-methylene-blue)[](https://www.straight.com/guides/health/best-methylene-blue-supplement/)

     - **Unique Features**: Includes Liquid Gold for enhanced absorption and photodynamic activity, making it a standout for biohackers and wellness enthusiasts.
   - **Pros**:
     - High purity and rigorous testing.
     - Affordable compared to premium competitors.
     - Positive reviews for cognitive and energy benefits.
   - **Cons**:
     - May cause temporary blue staining of teeth or urine.
     - Not recommended for pregnant or nursing women.
   - **Availability**: Widely available on Amazon and the brand’s official site.

2. **AccuaBoost Premium USP Grade Methylene Blue**
   - **Why It Stands Out**:
     - **Advanced Formulation**: Features a proprietary electron transport chain optimization technology, maintaining bioactive MB levels 4x longer than competitors, per lab testing. Achieves 99.9% USP-grade purity.[](https://consumerreportsusa.com/Methylene-Blue)
     - **Performance**: Outperformed others in laboratory tests for mitochondrial activation, cognitive enhancement, and antioxidant properties. Participants in a 28-day study reported significant improvements in energy and mental clarity.
     - **Value**: Priced at $34.97 (down from $42.99), it offers a strong performance-to-price ratio, with free 2-4 day shipping and a 30-day satisfaction guarantee.
   - **Pros**:
     - Superior bioavailability and stability.
     - Heavy metal testing to parts per billion (ppb).
     - High customer satisfaction (+10,000 5-star Google reviews).
   - **Cons**:
     - High demand leads to occasional stock shortages.
     - Only available through the official website, not retail stores.
   - **Availability**: Direct-to-consumer model, primarily through the brand’s website.

3. **NBL Methylene Blue (Norwegian BioLabs)**
   - **Why It Stands Out**:
     - **Quality and Effectiveness**: Rated 9.8/10 in reviews for its ultra-pure, pharmaceutical-grade formula without fillers or additives. Known for fast absorption and rapid cognitive benefits.[](https://avasreview.com/top-5-methylene-blue-2024/)
     - **Benefits**: Strong antioxidant properties, supports mental clarity, cellular health, and energy. Ideal for daily use with a convenient dropper bottle.
     - **Customer Support**: Offers free shipping, a 1-year warranty, and 24/7 customer support, enhancing trust.
   - **Pros**:
     - High purity and no formaldehyde.
     - Fast-acting with noticeable cognitive and energy boosts.
     - Competitive pricing for long-term use.
   - **Cons**:
     - Frequently out of stock due to high demand.
     - Slightly bitter taste reported by some users.
   - **Availability**: Available through the brand’s official site, with limited stock due to popularity.

### Why These Brands?
- **Purity and Safety**: All three brands emphasize pharmaceutical-grade MB, third-party tested for purity (≥99.7%) and free from contaminants like heavy metals or formaldehyde, which is critical for safe human consumption.
- **Consumer Trust**: High ratings in reviews, with Earth Harmony and AccuaBoost frequently cited in 2025 supplement rankings for their effectiveness and value.[](https://consumerreportsusa.com/Methylene-Blue)[](https://supplementinstitute.org/vitamin-supplements/best-methylene-blue)[](https://avasreview.com/top-5-methylene-blue-2024/)
- **Market Trends**: These brands align with the growing popularity of MB in biohacking and wellness communities, driven by endorsements and social media buzz, particularly on platforms like TikTok and X.

### Notes and Considerations
- **Global Context**: The rankings are based on sources primarily focused on the U.S. market, as global data on MB brands is less centralized. These brands are prominent in North America and likely have international reach through online platforms.
- **Regulation**: MB supplements are not FDA-approved for cognitive or anti-aging uses, so consumers should prioritize pharmaceutical-grade products and consult healthcare providers, especially if taking medications like SSRIs.
- **Alternative Brands**: Other brands like Compass Laboratory, Suppvana, and Meraki Medicinals also rank highly in some reviews but were edged out due to higher pricing (e.g., Compass Laboratory at $136/bottle) or less consistent bioavailability data.[](https://www.straight.com/guides/health/best-methylene-blue-supplement/)[](https://metapress.com/finding-the-right-methylene-blue-supplement-a-science-based-guide/)

If you’d like me to search for more recent posts on X or additional sources to confirm global brand rankings, or if you need specific product comparisons (e.g., pricing, dosage forms), let me know!