路易斯出生於紐奧良貧民區，自幼父親就離開家庭不知所終。他曾因犯事進過少年感化院，並因此在那裡學會了吹小號。 18歲的時候他成為了娃娃歐瑞(Kid Ory)樂團的短號手。 1922年，他加入奧立佛國王Joe King Oliver樂團，師從奧立佛。
1927年以他命名的樂隊Louis Armstrong And His Stompers誕生，這時他開始以自己的略帶沙啞的歌聲聞名，代表作“多美好的世界啊”（What a Wonderful World），1968年首次錄製。
"What a Wonderful World" is a song by Bob Thiele, George David Weiss, and George Douglas. The song was first recorded by Louis Armstrong and released as a single in 1968, and was inducted in the Grammy Hall of Fame in 1999.
Armstrong died just after a heart attack on July 6, 1971, at age 69, 11 months after playing a famous show at the Waldorf-Astoria's Empire Room. Shortly before his death he stated, "I think I had a beautiful life. I didn't wish for anything that I couldn't get and I got pretty near everything I wanted because I worked for it." He was residing in Corona, Queens, New York City, at the time of his death. He was interred in Flushing Cemetery, Flushing, in Queens, New York City.
01.What a Wonderful World 2:17
03.Home Fire 3:18
04.Dream a Little Dream of Me 3:16
05.Give Me Your Kisses 1:59
06.Sunshine of Love 2:53
07.Hello Brother 3:31
08.There Must Be a Way 3:08
09.Fantastic, That's You 2:58
10.I Guess I'll Get the Papers and Go Home 2:47