右乳乳腺癌，浸润为主型，浸润性导管癌II级，癌周浸润III级，淋巴管侵犯(-)，血管累犯(-)，神经累犯(-)。酶标：肿瘤细胞 ER(-)， PR(-)， PCNA(+++)， K1-67 30%+，P53(+)， CerbB-2(-)。右乳房根治标本，乳头，残腔，基底部未见肿瘤累犯，癌旁病变：慢性乳腺病，腋区淋巴结18只未见癌转移。
3。我妈是不是应该用适合腋淋巴结阴性的化疗方案呢？那到底哪种化疗的组合反应相对较小呢？CMF，AC/EC， CAF/CEF， TC？她准备国庆长假以后就回医院开始第一次的化疗。
Just get a short time, let me answer some of the questions:
The pathology report missed one important info: the size of tumor (clinically 2 cm, but pathologic size more accurate).Usually margin status should be mentioned, though with mastectomy it is not as important because they should be negative for small tumors.
Your mom's breast cancer is called triple negative breast cancer (ER, PR and Her-2/neu negative; if you want to search online, you could look at this specific type); this is an aggressive type of cancer, but her is in early stage. High levels of PCNA, and KI-67 are consistent with the aggressive nature of her disease. A lot of triple negative breast cancers have p53 mutation, it is not surprising to see that her p53 was positive which also makes her tumor more aggressive as well.
Though aggressive, but still early stage, the cure rate is still very high. She does benefit from chemotherapy. Because she has modified radical mastectomy and tumor is small, radiation is not needed. Adequate number of lymph nodes were dissected, which gives us confidence that her lymph nodes are indeed negative. Chemotherapy is usaully AC+taxol in this country (if not this type of cancer, taxol may not be needed if nodes are negative). Some use dose dense chemo (shorter interval between doses), which may be more effective in her case. Currently there is trend to treat with TC omitting adriamycin due to cardiac toxicity, people say it is equally effective.
Good luck with your mom's treatment.