酯可以说是合成化学中最常见的官能团了,除了广泛存在于活性分子中,也是羧酸最常用的保护基了。常见的酯有叔丁酯,甲酯,乙酯,苄酯,烯丙醇酯,还有三氯乙醇酯等等,水解方法各不相同,有加碱的,有氢化脱苄基的,有锌粉还原脱保护的。对于非手性的酯,只要拿到产物就可以,没有手性问题需要考虑。然而对于手性的酯,如果消旋了,就非常的麻烦。
![](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAcwAAACqCAYAAAAgAX91AAAgAElEQVR4nO3df2wb53348Te/SGICsSMaqBvazVa6rRSpyBB5NVIqZRZqxToaDWLSy1YqazYHyh8KHMTUoiDyjEL2BkUKFpTCIEPeD8MpbEzK/ogkD4HcBR1V1Ji0TQI1IJ0kBwMZbCC1tpjoUpvotcDz/eN45yPFX5L5U/q8hIPs4/HuuRP5fO55PvfcWZRSCiGEEEIU9P9qXQAhhBCiEUjAFEIIIUogAVMIIYQowQM7fWMqleLmzZv80z/9E/Pz86RSKebn58tZNiGEEGJH3G43AO3t7Xz1q1/F4/Fgs9nub6Vqm8LhsPL7/cpqtSpAJplkkkkmmRpi8ng8KhQKbTfsGSylXiW7trbGuXPneO+994x5TqeTkydP4nQ6gXsRXQghhKgVc4/n0tIS3//+97l586bxutfrZWxsDLvdvq31lhQwl5aWOHHiBGtra1itVgKBAGfPnt32xoQQQohaSCQSXL58mXfeeYdEIoHNZmNycnJbDb2iAXNqaoquri5SqRTt7e3MzMxIoBRCCNGQEokEXV1dRoszGAwSCARKem/BgDk/P09nZyepVAq/38/Vq1exWq3lKbUQQghRI729vYyMjAAwOTmJ1+st+p68ATMajdLR0cHa2hp+v5/x8fHyllYIIYSooeHhYc6dO4fVamVubo729vaCy+cNmD6fj6mpKZxOJ6FQSFqWQgghdp2uri4mJiZob28nHA4XXDZnwFxaWuLYsWNYrVYikYjkLIUQQuxKqVSKo0ePsra2VrRrNuedfi5evAjAW2+9JcFSCCHErmW1WnnrrbeAe7Evny0tzEQiweHDhwGIx+P3f2cEIYQQoo6ZW5nLy8u0trbmXG5LC/PmzZukUimcTqcESyGEELue1WrF4/EA2lDKfLYEzB/+8IcAnDx5skJFE0IIIerLt771LeBeDMxlS8BcWVkBKHp5rRBCiNwmJiZ48cUXmZiYqHVRRIn0blg9BuayJWBGo1EAHA5HhYolhBC70/z8PB0dHXR1dfFR7CO6urro6OiQJzk1AD3mra2t5V1my0U/FosFgBLvyS6EEHvelodTtAP9wDCwpM06ffo0Q0NDMvKgjh08eJBEIpE3/knAFEKIHUqlUoyMjDD8zjB3EnfABgwA5luTXgYuAmvQZGui/61+AoGA3AymDhWLfxIwhRBiB6ampujt7TXSWATQgmWuwQUJtKCp3boUh8NBMBgs6f6lonqKxb+cNy6oV5JIF0LU2srKCp2dnfh8Pi1YuoFlIEjuYEl6fjC9nEe7VsTn89HZ2cnS0lKVSi7uV0METEmkCyFqLZFI0NvbS1tbG7Ozs+AAJoEQYB7nvgR0onXFZmsFZtJTK8zOznLs2DF6e3tJJBKV3gVxv1QWQOWYXRPxeFydPn3aKBPtKCbSv9PzTp8+reLxeK2LKoRoEKOjowpQ3d3dBV9fWFgw5kUiEdVka9LqHSuKIRSbqIyfOIqee3UT7qzXc/0MoSw2iwJUk61JBYPBah0GkUOx+FeXLcxUKsXw8DCtba3aVWd6d0YY+Fb69xhgh/fee4/WtlaGh4dJpVK1LLYQooFcuXJFaymWYN4xz/86/hf8QATtClj9mp0U2tWwbWitSr2+CpWw4n5Qywp64E7ijtGC1R9uLOpL3QXMqakp2traOHfunHbVWQDtA5r9QOwetHxAQPugnTt3jra2toK3NRJCCLPOzk42Njbyvj7PPB100EUXv5j7BYwD5lEhU2iB8hzahT095K6vCrGjNQDCgFvLkZ44cYITJ07cu6BI1IW6CZiSSBdCVNPo6CgAgUDu6HaRi3TQwTzpayXMo0D0PKUPiKLVV3rP105vwd2O1iqdBBzafb1b21o5d+6c5DfrRM0DpiTShRC14HQ6GRwczOiaTZHi7/l7AP6Ov8v9xl7gGDCL1jocR6uvynU3US9aI2AA7nLXSE9dvpyr8hNVtd2kZz6SSBdCNAJzXZRMJpXL5VKAGk+OK4dyKEbTdc1CnvqlP11fDeSor8r9E0fhv1f/uVwuFY1Ga30Id61i8a/sLUxJpAshGsX+/fu5cuUKAF2BLqKUkDMcQKuvLpDZTVsJegt2DjgJH9/+mEgkUuGNinwq0iUriXQhRKNoaWnh7OhZuILWzVqMlcz6qhqcwB1I/ERSTLVU9oApiXQhRKPxnvGCC63+uVPr0oh6VfaAKYl0IURDupL+fb6mpdBcACzAe7UuiDCrSJfs66+/jsvlorOzk4mNCdpo4wY3Cr/Jmp70/IC/AgWzon0Q0+v/r7X/4tVXX+WZZ57h008/rcAGhRANowUYrXUhRD2rSMCURLoQoiGdQeuaFSKHio3DlES6EKIenTlzBqUUX/nKV3Iv8CO0wQV5XhZ7V0VvXCCJdCGEELtF5e/0I4l0IUQdi0ajvHfhPW04mxAFVD5gSiJdCFHHotEo37v4PZiudUlEvavOvWQlkS6EEKLBlS1gSiJdCCHEblbzp5UIIYQQjaBiAVMS6UIIIXaTigZMSaQLIYTYLaRLVgghhCiBBEwhhBCiBBIwhRBCiBJIwBRCCCFKIAFTCCGEKIEETCGEyCVFaU9aEnuGBEzREOLxOLOzs2xsbBRc7vbt29y+fbvg6zu1uLjI4uLijt47O9s4Ne/t27eJx+MlLbu4uJj3b7LTY1U3htGetOQD1qq87dNACPBUebuiIAmYoq4sLi5y6dKlLfNjsRidnZ0cOHCAlpaWvAHoo48+4vHHH+eVV17J+Xp/fz8Wi4Xr169vu2zz8/McP36clpaWooHbbHFxkc7OTk6dOlXS+27fvl0wwBY6cdjY2ODGjRsFt3P9+vWMZW7fvp0R3D766COOHDliHMPbt2/nPV5jY2McOHBgS3lnZ2c5fvw4zzzzzLaOVV1xoD2jdwo4iva0o1QVt+2m+s8IFgU9UOsCiL1rcXGRiYkJAN59912am5s5e/YsoFXSLS0tW97j8/n4+OOP6ezsZHV1NecyAMeOHSu47ba2th2X+4knnmD//v0lLz82NgbA+fPnSSaTLCwscPz4cS5evIjD4eC1114DYHR0lGg0yrvvvgtoJwmHDx/esr7Ozs6MY2X2gx/8gMnJSXw+Hx988EHO8nz961/nyJEjAIRCIY4fP86BAwfw+XwMDw8by+nHsLu7m1u3bvHYY4/hdrsz1vXqq69y5coVOjs7UUoZ8//xH/8RgDfffHNbx6qmLGgB0Zr+/2nAC1wERtK//wIIAv4qly0FPAIPNz1MIiEPvK8ZlQXtFunZs7ctFApp6zqNqpufAW3fuGqa59bmhUKh+95nsTPXrl1TgBocHDTmTU9PZyyzsLCgAOXz+dS1a9dUX1+fGhwcVMlkMmO50dFRBajR0VFjXnNzs3K5XCoUCimfz6cAtbCwsO1y6uv2+XxbXsu3vlgspgDV3NysBgcHje/X6upqxuv6d868n7kkk8mCr+fa/1z0snR3dyultOOtl0N/bXR01Ph39t/DDFAul0stLCyovr4+o4xAxt8nFoupvr6+guuqhaWlJfVUx1NamR0oJnPUHcsoPBj7hRtFuEr11mS6XKB+rf3XFKD8fr+Kx+O1PnS7TrH4V/0uWUmkiyz/+q//CmgtN9DylSdPnuTUqVNcunSJS5cuMT8/D8DHH3/MnTt3cDgcNDU1sbCwkHOdExMTLC4uEo/H+eSTT7h169aW1tFOffzxxxn/v3HjBsePH+fNN9/csux3v/tdQGtB/+qv/ioA165dM1rGeiuwr6+vpG2vrq7uuNxmL7/8Mn19fYyMjNDS0sLPf/5zAFwuF01NTYDWWj1//jzT09M8//zzxns3NjZ4++23uXTpEhaLBQC/38/8/DwOh4NAIABoLdPvfe97xt/wgw8+wOFw8B//8R911U375JNP8v7fvI/H44EoWs6yE1gyLdQKzKSnVrQ67BjwKpXLby5xL4caBY/Hwx+d/SPsdjsTExMcPXqUCxcukEpVq59YVL+FqbfyvCjiVTpD038iKEJZ25UWZs25XC4FqFgsppS618rSW0mxWMxoAeVrWSmltST1z68+dXd3K0D19fUppVRGC7PUFs/CwoIaHBzM2ULUy5WrtWtuXer76fP5VCwWU9euXTNaYnrrbHp62mghmlvb2WXR1zk6Orpl0vcvVwtzdXVV9fX1GcdZqXvf0+npaeM7YG5J68c+3zHKVV/4fD7lcrm2HA/9eOnHrh7NzMyo1tbWe5+hnjz1VBCFLb2MLf3/cv3E09tNl6G1tVXNzMwYZdzc3FT9/f3KarUqQNntdjU+Pl7Do7Z7FIt/1Q+YV1HY0x8GK1oA3axYiCz+IwGzpsxBJZlMqunpaaOL1uVyZQQDc8AcHBzM+JuZuwH1gKNX3HrAHB0dNYKq/n99MneRZr+mr1Nfl8vlUteuXTOCZb7uWD146eU2/zYH9GQyqa5du5bRTWoOamarq6v31SWbHVD7+vqMQK7PN099fX1GWXOVyVxf6F2yLpfLOIb6evv6+oyTF/1vXc+CwaBqsjUpQFlsltwBcT0zsNGKYuY+66NgenugmmxNamhoKG8ZI5GI8nq9xvadTqeam5ur4lHafWofMF/OERDXUQRMHzQ7ivEaBMtNFM+jHm56WE1OTt73Povt04Njc3PzlhZidqWvByv9s2UOGubAZj4BMrfwlFLbzmFmt+j0yt/lchnBLpdYLHbvO5DeF/Nvl8ulYrGYsd96MC6l9VWohakHpXwBU98fPQDqy+rHJd/y+QK0vi49sGYHQ31/FxYWVHd3t9HSbwTr6+sqEAgUD4hhjBNvQMt1RrZZF82k159eR09PT8k5ylAolNEqlvzmzhWLfxXLYR48eJCnOp6Cq0Abmc/FtKFdabaMNs5oDehia96gkqbS5boBXzj6BXw+H11dXaytVXvA1d72J3/yJ4CWv9RzmD6fD4BwOGyMm9SHLdy6dYsPP/wQgNOnTxvr+cEPfkB3dzfd3d0A/PjHPzbeMz4+vuPyff/739+yLYfDAWhXkea7AvTw4cMFc6aHDh0iFovxySef8Bu/8RscOnQIgCNHjhjDPvJZXV3l7NmzhMNhTp06xZkzZ4xpZGSE1dVVzpw5k/O9X/nKV/D5fAwODvIv//IvAPzWb/0WP/3pTwscheL8fu2y0SeeeII/+IM/4NSpU1uGonz729/mz/7sz+5rO9Vks9kIBoOEw2Htb7kCnEhPK6YF29HGTE6iDQe5iVa3XChhI1nrdLvdhMNhxsbGsNtLG1PidrtZXl4mGAxis9kkv1lJ242w2xGJRJTH4yl+ZVnW2VXevEE5frLOBj0ej7p69aqy2+0KUFarVQ0MDKjNzc2yHAOR38LCgtGq9Pl8ebsts/+vvydX687ckvP5fFtyb+YW5urqquru7i7YqtO3GYvFMtatd8fm6zrNfn/2vvl8PqNVNjg4aOyTubWYr/VarNWnlDK6twuVz+VyGa1vvZz5umSLtTDNZdL3MRQKZbQwG93k5KRyOBz3PosBtN6y7F6rIbS8ZqBAPZTVy+ZwOMrSy7W+vq56enqM9drtdqMuM/cu5JqKfRf2gmLxr6IBUyeJdJGLnocsFjCzu1v1L3cu5qCWTCa35CRz5TCvXbuWc116UNS7EbPXXSxoKaW27IP+Wy+HHtDzdYlm03OY2cNUzMeor68v41jmonfH6vuW73tfSpdsc3NzzoC5urqaETBjsVjDV8qbm5tqaGjoXn7TblGM5alvsoOp/jOWfl8FT9DD4bByu93K7/cb87IvpjMzpx72sroImDpJpItcsitaPZ+XHQzM8/NdpFXqRS+ltHj0oKa30rLXrQfUfAFX37dcLczm5uaMfTAHTD3IZweW1dVVI9+ZTCaNgDk4OJgxnjOZTGa08nLRW47mXO92A6YevLu7uzOWM6/LnPctdoLSSOLxuPL7/fc+p+1oV+AX+gmll0u/pxq5RnMgLhQwlbr3ed7LF0AWi39VHYcZCASIRqIEAgFUQkEvWl//TdNCNmAMCKPdGsrcxx/d5gb1XEIvqISip6eHleUV+vv7877F4XAwOTlJKBSitbWV+fl5Ojo6JL9ZRbdu3QK0MYFmTqcTgObm5rKNqczn+vXrfPLJJ0xPT+e82w7A888/T3d3Ny+99FLBnKPL5eLrX/86gPEb4MMPPzTGKOpjO83jFf/5n//ZWPb27ds899xznD17lh/96Eesrq5y/vx5XC4Xr7/+Ot/5zncA7W5B+/fvN9an39EHtPGT169f59SpU8bdhLKPo14efdLvxJTLysrKlnWYx6ia70fr9/uNPOu3v/3tvOtsFHa7nfHxcebm5rTPZdaYyQxZYzudTidzc3OMj4+XnKfcKavVWnyhtM997nOAlv8XeWw3wpaL3mWgbw8P2t00sn9Md7kwhqEU+8m6K4fb7VbhcHhH5QwGg8pms1W0+2SvI93iMrdOzEMdsrto9c+nz+fbMl6xHC1MveWUnf80t5Z0yWTSaPlmb9Pc7ZndJZvdYivWJRsKhYycpl4+vaWpd2u7XC6jTIW+x/ry5u43fR+yFWph6q1U8zhZc066u7t7V+UwCxkfHzeug7BYLVo9ta7VVxarpS7SPMVamPoV69LCrJMu2VwkkS70ClbPcenBqq+vzxhor1fO+pdar6Czv/z3GzD1AJhroH6+YGcOms3NzUYXrh6YFhYWMiqrnQRMnb7/+i3o9OAJ94ak5Bp2Y5YrCG53WIn5pgt9fX0ZQ4L0QG4+6dntAVOpe9dB7LPuU4B64NkHFKD2Wfep/v7+mp9oFwqY2Sdde1XdB0ylJJG+1w0ODqqFhQWVTCaNlmb26+aAoF/dWY6AubCwoHw+X8ade8wnOLFYzAh4etDOd8GRfvcenX7xjb4ePS9ZKGDmCyz6XXquXbu2Jafq8/lUKBQy3qufdOTLFepBt1DA1K8izhcwzVcJ6xf3ZLcmzblU/Ypl/VjuZvp1EM8++6zyer0qEonUukhKqeIn9/pJ2F7WEAFTJ4n0va27uzvjZgDJZNIY7G7+Ipsr4uyB8OZby+k3D881wD97yg52ZuaWb6mtJb07Nl+5swNQqV2X+nARvWVnXl4PhPr68+1PrtsM6icDOvMVrtnd03rrMntec3Nzzpa5+WRDb8Xs9qCplFLRaLTWRciQq65aXV01egKkJ6zBAqZubm5OOZ3Oe4HTy9Y7Z0TS89PL1Opq1mIBs9jrQqPfGSd7XqEz3lxjDCvZgpmeni75DHx1dTVnBaTn+7LXo7foCtFvoVcs/1psbKi+nLkM+d4XCoW2zNdbldnlL2W7sVispOVE+eWri8w5773+t2nIgKmTRLoQQpRHKTnMYuOKd7ti8a/6j/faBr/fTyQSob+/n4d4CC7CA94H4CI8xEP09/cTiUSM23LVm9nZWV566SVcLlfFh0EIIcROud1uBgcHmZyc3HJLQ3FPXQdM0MYRDQ0NsbK8gtfr5Wt8Da/Xy8ryCkNDQ9saZ1RJr732GhaLJWPq7Oykr6+PmZmZWhdPiIZz8+ZNHnroIb75zW8yMTFBIpGodZF2tddff53m5mZeeukl4x7OIpMl3Qy9NyP9QNis2XXj008/5fOf/3yti2FYXFzk+PHjjI6OGje8vn37Nt3d3Rw6dIjh4WHjYcFCiO35whe+QCQS4ZFHHuHu3bs8/fTT/N7v/R5er7fig/7F3lMs/tV9CzNbPQXLfFpaWpiZmWFycpLHH388444nQojSffe736WpqYmf//zn3L17l1AoxBtvvMEXv/hF2traGBkZIRrd7i3AhNiZhmth1ptcLUzd7OwsnZ2d+Hw+PvjggxqVUIjGdujQIX72s5/lfG3fvn08+OCDHDp0iBdffJEXXniB9vb2Kpew8SwtLTE1NZUxr729Ha/XW6MS1Ydi8e+BahZmr9ET6efPn+f69eu74h6a9yuRSDAyMlLrYogGsn///rwB8+7du9y9e5eNjQ3eeecdRkdHefDBB/nd3/1d3n77bWw2W5VL2xhWVla4ePFixrz+/v49HzCLabgu2UYjifRM0n0mtuvBBx8sablf/vKXACSTSW7evCmftQJy5X8fffTRGpSksUiXrBCibqVSKT73uc/x3//93zlfb2pq4n/+53/40pe+xHPPPcfXvvY13G63tCyLiEajHD16NGPe+Ph43Q7RqxbpkhVCNKzR0VHu3r1r/L+pqYlUKsWRI0fweDx84xvfwOPx1M3wskaRq4UpVx0XJy3MMpJEuhDlE41GaWlp4Re/+AWtra10dnbyjW98Q1qQZXLw4MGMsa2RSASHw1HDEtWetDCrSBLpQpSPzWbjb//2b6UFWSF2uz0jYEoLszi56KeMJJEuRPnYbDa8Xq8Eywox11c2m02OcwkkYJZRru4MOWsTQtQjc30l9VRpJGCWkSTShRCNwlw3ST1VGgmYZWS1WrdcjLDXk+hCiPpkThfVYz1148YNnnnmGeNhFi0tLVy6dImNjY2M5RYXF7FYLFy6dCnneoq9vh0SMMss+0xNztyEEPWoXluYGxsbnDp1ipMnT/Lmm2+STCZRSvGXf/mXTExM8Ou//us1uwmMBMwyk0S6EKIRmOuqero48c///M+ZnJxkdXWV559/nv379wParUb1RyV2d3fXpGwSMMtMEulCiEZQj3XVxsYG58+fZ3BwMOdjEffv38+7777LrVu3mJ2drXr5JGCWWb12cwghhFk91lULCwsAPP3003mX+c3f/E0APvzww6qUyUwCZpntlkS6EGLnJiYmePHFF5mYmKh1UfJKJBI89thjfPazn+Xhhx+udXEA+PGPfwzAgQMH8i6jd9H++7//e8b81157zajXzNPx48fLVj4JmGVWj2dtUN+JdCF2i/n5eTo6Oujq6iL20Ud0dXXR0dHB/Px8rYtmSKVSDA8P09bWxn/+53/yk5/8hKeeeore3t6MO/80mtHRUZRSWya91VoOEjDLTBLpQuw9a2trvPzyy0ZwbAde/dnPaCcziK6trdW0nFNTU7S1tXHu3DkSiQSBQICBgQGsVisjIyMcPXq0ps+r/ZVf+RVAe0RbPnpv2Be/+MWqlCmDygKoHLNFiSKRiHEMx8fHa10cpZRSyWRSAWpwcDDvMtPT0wpQoVCoiiUTorFtbm6qoaEhZWtqUoCygxoDpUzTWHo+oGxNTWpoaEhtbm5WtZzLy8vK4/EYdZPH41HLy8vG6/F4XPn9fuP11tbWmtQFel3V19eXd5nsumphYUEBanR0NOfyxV43Kxb/JGCW2ebmpnEM6yX4hEKhouUp5YMqhLhncnJSORwO4/seALWeFSz1aT39ur6sw+FQk5OTFS/j+vq6CgQCJW93bm5Otbe3G8t7vV4ViUQqXk6zwcFBBajV1dUtryWTSdXc3KxcLpcxr5oBs6G6ZCWRvjP3k0gXQmRaWlqis7MTn89HNBrFAywDQSDfQ8ds6deXAQ/ao8t8Ph+dnZ0sLS1VpJzmLlabzcbQ0BDLy8sFn57kdDoJh8OMjY1ht9u3dOGW29raGl1dXfh8PmPe66+/js/n4/HHH+fGjRvG/MXFRU6cOAHAlStXyl6Wkmw3wtbC3NyccjqdClDPfuYzClBOp1PNzc3VumgGo2vGZjOOIaACgYBaX1+vadlGR0cVoBYWFgouByifz1elUgnRWLJba62gZvK0KBWoSVBOUHM5XptJv19fV09Pj4rH42UpZygUymgl7nTd6+vrqr+/X1mtVq272W4vW5ppc3NTDQwMGOu22Wxb6snp6WnlcrmM/XC5XGp0dFQlk8mM5aRLNi0ej6vTp08bZWoHNZH+rc/z+/1l+6Dt1JaumUBgy4chGAzWrHyl5CelS1aI/ILBoJGntFksaqhAoNQnrzkggornWGYovT7S+c37qScikYjyer3GNp1OpwqHw/e977nWez+NlfHxcWW32+uqUaFryIApifTy2kkiXQih1MzMjGptbS0a+PJNGfVUOkBuZi0TT6/XXE/MzMyUXMbNzc2KtQQLHYvtNlbC4bByu91568t60HABUxLplbHdRLpSquplFKJeRCKRjJNhN6jwNgJlwXoKrbs2e7lwejvbCSjm1prValUDAwMVbzgEg0Ej9WSz2Yo2VuLxuOrp6dnxCUE1NUzA3HL2AWq5xA/kcnp548PtdpelKyKX7X5YzMbGxjI+3P39/RXpitBbtl6v15iXTCaVz+dTgJqenjbmLywsKJfLpZqbmzOC6ebmpnI4HHX94Rai3Iy83b59BYPbTqYt9VSeIDyZ3m6hLkvzdR21SE2V0mjIvq6j1qmpUtR9wJREen0m0iORSMb+1mP3iRDlNDY2puyPPqqd0FosaoCt3aflmGayAyJbe9E2QQ2AsqaXsT/6qBobG9t6XUd7e03TKNlpqaefflotLy+rmZmZjJ7Cnp6euslTFlLXAVMS6fWfSDe3iustQS9EOUSj0YyTSH+eeqWc06ZeT3EvvxnMsVw8XR5zgNRPtMfGxmp96Ay///u/b5TxscceM/4NqL/6q7+qdfFKVpcBUxLp+Y9FPSbS9Vaxvo16+7IKcT9CoZD6rM2mfofcPVeVnLbUU+TuYZsDdRKU88tfVm+88UbdnbQODAwoQL3wwgvqy1/+snI4HOqJJ55QjXYhYV0FTEmk59cIifTs7pdadwcJUQ76nbBOVzlYZgdEp7meYus1HHo9Vo/fOT1gXr16Va2tranNzU3jRL4ey5tPXQRMSaSXfpwaIZGe3SquxVW/QpRLPQRMfRrnXu+Zt0EDpk4C5g5IIn37GiWRbm4V61f9VnssrBD3K1fAvJr+jg3UIGhugupn64m/BMzKq1nAlET6/WuERPr6+npG17DH46l1kYTYlnoLmPkmCZiVVyz+Vezm65FIhNsff8zvAHPAOFDpxylbgX60Gxz3AAmgF2gDbpqWs6fLMwecBKz/93+88cYbLC8v09PTU+FSlu5LX/oSAC+88KH4gv4AAAmnSURBVAKPPPIIDoeDJ554IuO1WrPZbIyNjREOh3G73QwMDNS6SEIIUREVfVrJTxIJDgDOSm4kBzswhhYQncAKcCI9rZiWcwJ3gPl/+zeee+45bLZ8zxqorW9+85v8wz/8A8vLy3zmM5+pdXFyam9vJxQK4XRW+68thBDV0VCP99ouJ5mt25vAuZqWaOceffRRrFZrrYshhBB7VlUD5nuABbhQzY0CfiCC1l0rHYZCCCF24oFaF6BarMBQrQshhBCiYe3qLlkhhBCiXCRgCiGEECWQgCmEEEKUQAKmEEIIUQIJmEIIIUQJJGAKIYQQJdgzw0qEEEJUxoULF7hwIXOEfSgUqlFpKkdamEIIIUQJJGAKIYS4L4uLi7zyyitYLBZjevPNN4nH47UuWllJwBRCCLFjb7/9NsePH+fYsWPEYjGUUqyurrK+vs6RI0e4ceNGrYtYNpLDFEKIOjMPOKj8IxHv1+zsLOfPn2d6eprnn3/emN/S0sJf//VfA3Dy5ElisRiHDx+uVTHLRlqYdezChQsopTh9+rQxLxQKoZTC7XbXsGRC7G4eIAScLrZgma0BXUAH8E6Vt70T3/nOd3C5XBnB0uxP//RPAbh69Wo1i1UxEjCFECKLHXCjtfKqIQUMoz3sfgKwAY9Xads7tbGxwa1btzhx4kTeZQ4fPozL5eK9996rYskqRwJmHdsriXQh6oEFLXBV2xRaoDwHJIAetMcR9piWSQGPVL9oBa2urgLQ1NRUcLlDhw7xySefVKNIFScBs07tpUS6ELV08OBBOp56iqtogWuqSttdAU4APiCK1qINA2NoLUydHlBvAB1PPcXBgwerVEKRbU8FzHm0HEG9MyfSz5w5YyTL9UR6d3c3J0+elJamEGXw5JNP8jfvv4/H4yGKFsA6gaUKbS8B9KIFwZto3b6TaDnTdtNyS+ly6AHV4/HwN++/z5NPPlmhkm3PkSNHALhz507B5X7605/S3NxcjSJVnsoCqByzty0UCilAnQal0lMcVAhUxDSvGlMclD+9X4Gs19zp+aFQ6L73uVxcLpdyuVx5X4/FYgpQg4ODVSyVELvfzMyMam1tNerBnnT9Ua66aAyULb1uG6ghUJs56que9DKAam1tVTMzM7U+NDm5XC7V3Nyc9/VGq6uKxb+qBsxqT5vpD6T5AzpW5wEzmUyW9AEr9kEVQuxcMBhUtqYmrd6wWFTwPuuiEKh2UxD05wnEwfT2AGVralLBYLDWh6IgvZ6/du1azte7u7sVoGKxWJVLtjPF4l/Fu2Qlkb49ezGRLkS9CQQCRKJRAoEACaUyulC3Y43MLl4nMAeMkznG8mZ6/b1AQqmM7dczt9vN4OAgL730EpcuXWJjYwOAeDzOK6+8wpUrV5ient4VYzChgjlMSaQLIRqZzWYjGAwSDodxu91G3XICrZ4pZhg4ilbX2NGC5Bxa0NRlr9PtdhMOhwkGg9hsNhrBH//xH7OwsEA4HObAgQNYLBaeffZZDh48SCwWyztGsyFtt0m6HZFIRHk8HmOdblDhCnW/rqPlJ/VtOUBN5lgubOqGBZTH41GRSKQs+1sOpfb5S5esENU1OTmpHA6HUXcE0vVOvjppAJQ1/Ts7T7mlvnI41OTkZK13cc8rFv8qGjB1kkjfnt2WSBdit9jc3FRDQ0NGftNusWy5LsJ8DUWuem4s/T7SecqhoSG1ublZ610Tqk4Cpk4S6aXZbYl0IXabeDyu/H6/Ufe0p+ujbdVXfr+Kx+O13hVhUlcBUyml1tfXVSAQuNfSAzWzzUAZB+U1ffCcoOZyLDeTXr/RhRIIqPX19YrtWzkNDg4qQI2OjqpkMqmU0lqWerCcnp6ucQmFEHNzc8rpdBp1jJetw+Yi2fWV06nm5uZqXXSRQ90FTF04HFZut9vYngfUcgnBcggtLwAoO6jxHMssp9dn5E7dbhUOhyu+T+W2sLBgBEhANTc3q76+PmlZClFnxsfHld1uV4CyWixqAC1POZD+P6DsdrsaHx+vdVFFAXUbMHWSSBdC7Aabm5uqv79fWfftU4B69oEHtAC6b5/q7++XPGUDKBb/LOmFDBaLRb96tqSrbMshlUoxMjLCO8PDJO7cwW6xMKBUxphJY1m0cZXZz4m7DFy0WFhTCltTE2/19xMIBLBarRUvvxBC6KLRKL29vayvr3Pw4EGCwSAOR7WeeyLuR7H4VxcBU7e2tkZvby8TExOAdl/FINpYynxm0Qb76vd99Pv9BINB7PZ6f/SqEGI3+/TTT/n85z9f62KIbWiogKmbn5+nt7eX+fl5ALxogdN8jhZFC5T6DRGcTifBYBCn04kQQgixXQ0ZMHUTExP09vaytraG1WLhLaUIACPAOxYLKaWw2+0Eg0H8fn+tiyuEEKKBNXTABC2/efHiRUaCQVJ37/LsAw/ww1/+Euu+fQR6exkYGJA8pRBCiPvW8AFTJ4l0IYQQlbRrAqZOEulCCCEqYdcFTCGEEKISisW/ij8PUwghhNgNJGAKIYQQJZCAKYQQQpRAAqYQQghRAgmYQgghBBQd078lYOr3YF1bW6tMiYQQQogGtCVg6jcDkIAphBBir0gkEqRSqYI3xMkbMFdWVipXMiGEEKKO6DGv0JOutgTMr371qwBMT09XqFhCCCFEfdFjXqEnXm0JmF6vF4CbN2+SSqUqVDQhhBCifkxNaQ+LPHnyZN5lcnbJtre3k0gkjBUIIYQQu9XU1BQrKyvY7fbttTABBgYGAOjt7ZVWphBCiF3t4sWLALz11lsFh5bkDJherxen08na2hq9vb2VKaEQQghRYyMjIywtLWG32+np6Sm4bN4bF4yNjWG1Wrl8+TKXL18ueyGFEEKIWpqdneXcuXMABIPB7d+4QNfe3s7Y2Bigdc1OTEyUsZhCCCFE7czPz+Pz+UilUgQCAfx+f9H3FLw13unTpwkEAqRSKbq6uoxILIQQQjSqy5cv09nZSSKRwOPxMDQ0VNL7it5LNhgMEgwGARgeHqatrU2unhVCCNFwZmdn6ejo4NVXXzValpOTk0W7YnUWle/R0jk29PLLLxONRgFobW3F6/Xyh3/4h7S2tu58D4QQQogKiUajTExM8P7777O0tARod/MJBoMldcNmUNuwubmpgsGgstvtCsiYrFZrzvkyySSTTDLJVM3Jbrcrq9W6Zb7NZlMDAwNqfX19O6HPUHILM9vs7CzT09MsLS0xOzu7k1UIIYQQFeV0Omlvb+e3f/u38Xg8JXe/5rLjgCmEEELsJfIAaSGEEKIEEjCFEEKIEkjAFEIIIUrw/wHEw1jaJAYUnAAAAABJRU5ErkJggg==)
在零度下,化合物1使用氢氧化锂,或氢氧化钠或者氢氧化钾作碱,用四氢呋喃/水做溶剂,有多达10%的消旋会发生。而当提高温度到室温或者使用甲醇作为溶剂,消旋比例会继续上升,高达25%。而当作者尝试使用氢氧化锂搭配双氧水这个条件时,在产率得到良好保持的同时,手性中心没有出现任何消旋,保持的很好。
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)
那么为什么会出现氢氧化锂/双氧水条件水解酯不出现消旋这个情况呢?(1)LiOOH的碱性相对而言弱于LiOH;(2)此外,由于它的较小的溶剂化能,HOO-相对于HO-而言,HOO-是有效的一个更小的亲核试剂。除了上述的非氨基酸手性酯类,氢氧化锂/双氧水这个条件广泛用于手性氨基酸衍生物,以及多肽类化合物的水解反应,如下面的例子所示,两个手性中心的小肽化合物,可以以90%的产率得到羧酸产物。
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)
来自网络
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