Stobbe condensation
文章来源: 张好古2022-12-15 19:59:52

The Stobbe condensation is a modification specific for the diethyl ester of succinic acid requiring less strong bases. An example is its reaction with benzophenone:

Stobbe condensation

reaction mechanism that explains the formation of both an ester group and a carboxylic acid group is centered on a lactone intermediate (5):

Stobbe condensation mechanism