my hunch instinct told me that if you go basic, you'll get Nobel upon solving the basic inquiry like:

1) How to sense your direction (GPS grit cells)

2) How to sense oxygen (2019)

3) How to sense mechano-pressure (to be determined)

4) How to get IQ (intelligence)

5) How to live longer (teleromase, teleomere)

....

Ref.:

By Kai Kupferschmidt

Science11 Oct 2019 : 167 Full AccessRestricted Access